Results 121 to 130 of about 1,779,977 (353)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Navigating the Complexities of Inter-Religious Peacebuilding: Implications for Theory and Practice
ReligionsAs conflict dynamics become complex and escalate globally, especially identity-based conflicts, we are witnessing an unprecedented shift in the Conflict Analysis and Resolution and Peacebuilding field toward contextually innovative and effective ...
Charles Kwuelum
doaj +1 more source
'It's not all about the land': land disputes and conflict in the eastern Congo [PDF]
, 2016 Key points • Current interventions in land conflicts are focused on conflict management rather than conflict resolution. • Land conflicts are part of a wider governance problem and need political rather than technical approaches.
Mathys, Gillian, Vlassenroot, Koen
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Towards Just Institutional Approaches to Conflict Prevention and Resolution
Utrecht Law ReviewIn all societies around the world, conflicts arise. Some may be smaller conflicts between individuals and others larger ones between communities. It might be possible to prevent some conflicts from escalating, but, in all cases, conflicts will need to be
Rianka Rijnhout
doaj +1 more source
Conflict Resolution under Asymmetric Information [PDF]
We consider mechanisms for resolving conflicts between two agents who are uncertain about each other's fighting potential. Applications include international conflict, litigation, and elections.
Helmut Bester, Karl Warneryd
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Humanities & Social Sciences CommunicationsTransactional sexual relationships (TSRs) take varied forms, with research emphasizing TSRs’ inherent risks, primarily to women. In South Africa, Blessed relationships have emerged as a prominent type of TSR.
Gavin George +2 more
doaj +1 more source