Results 11 to 20 of about 744,123 (317)

Flecainide induces a sustained countercurrent dependent effect on RyR2 in permeabilized WT ventricular myocytes but not in intact cells

open access: yesFrontiers in Pharmacology, 2023
Background and purpose: While flecainide is now an accepted treatment for arrhythmias associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), its mechanism of action remains controversial.
Emma J. Steer   +5 more
doaj   +1 more source

A simple method for quantitating confocal fluorescent images

open access: yesBiochemistry and Biophysics Reports, 2021
Western blotting (WB), enzyme-linked immunosorbent assay (ELISA) and flow cytometry (FC) have long been used to assess and quantitate relative protein expression in cultured cells and tissue samples.
Mahbubul Hoque Shihan   +4 more
semanticscholar   +1 more source

Artificial confocal microscopy for deep label-free imaging [PDF]

open access: yesNature Photonics, 2021
Wide-field microscopy of optically thick specimens typically features reduced contrast due to spatial cross-talk, in which the signal at each point in the field of view is the result of a superposition from neighbouring points that are simultaneously ...
Xi Chen   +10 more
semanticscholar   +1 more source

In-vivo corneal confocal microscopy: Imaging analysis, biological insights and future directions

open access: yesCommunications Biology, 2023
In-vivo corneal confocal microscopy is a powerful imaging technique which provides clinicians and researcher with the capabilities to observe microstructures at the ocular surfaces in significant detail. In this Mini Review, the optics and image analysis
J. Chiang   +4 more
semanticscholar   +1 more source

Preoperative Evaluation through Dermoscopy and Reflectance Confocal Microscopy of the Lateral Excision Margins for Primary Basal Cell Carcinoma

open access: yesDiagnostics, 2021
Complete removal of malignant skin lesions with minimal impact on the aesthetic and functional aspects is the ideal of every dermatologic surgeon. Incomplete surgical excisions and tumor recurrences of basal cell carcinomas (BCC) commonly occur due to ...
Mihai Lupu   +4 more
doaj   +1 more source

Multiview confocal super-resolution microscopy

open access: yesNature, 2021
Confocal microscopy1 remains a major workhorse in biomedical optical microscopy owing to its reliability and flexibility in imaging various samples, but suffers from substantial point spread function anisotropy, diffraction-limited resolution, depth ...
Yicong Wu   +26 more
semanticscholar   +1 more source

Feasibility and Implementation of Ex Vivo Fluorescence Confocal Microscopy for Diagnosis of Oral Leukoplakia: Preliminary Study

open access: yesDiagnostics, 2021
Background: Oral leukoplakia is a potentially malignant lesion with a clinical impression similar to different benign and malignant lesions. Ex vivo fluorescence confocal microscopy is a developing approach for a rapid “chairside” detection of oral ...
Veronika Shavlokhova   +9 more
doaj   +1 more source

Combining mKate2-Kv1.3 Channel and Atto488-Hongotoxin for the Studies of Peptide Pore Blockers on Living Eukaryotic Cells

open access: yesToxins, 2022
The voltage-gated potassium Kv1.3 channel is an essential component of vital cellular processes which is also involved in the pathogenesis of some autoimmune, neuroinflammatory and oncological diseases.
Nikita A. Orlov   +6 more
doaj   +1 more source

Corneal Confocal Microscopy: A Biomarker for Diabetic Peripheral Neuropathy.

open access: yesClinical Therapeutics, 2021
PURPOSE Diagnosing early diabetic peripheral neuropathy remains a challenge due to deficiencies in currently advocated end points. The cornea is densely innervated with small sensory fibers, which are structurally and functionally comparable to ...
I. Petropoulos   +11 more
semanticscholar   +1 more source

Raman imaging of protein in a model cheese system

open access: yesJournal of Spectral Imaging, 2020
Raman confocal microscopy is an increasingly useful technique when applied to food samples; it has the unique ability to interrogate the chemical structure, aligned with the same confocality capability that is available when using standard confocal ...
Elizabeth Nickless, Stephen E. Holroyd
doaj   +1 more source

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