Results 81 to 90 of about 739,261 (262)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Study of the possibility of increasing the probing depth by the method of reflection confocal microscopy upon immersion clearing of near-surface human skin layers.

, 2002
The possibility of increasing the human-skin probing depth by the method of reflection confocal microscopy (RCM) upon decreasing the amplitude of spatial fluctuations of the refractive index of the upper skin layers is considered.
Meglinski, I. V., Churmakov, D. Y., Tuchin, V. V., Bashkatov, A. N., Genina, E. A.   +4 more
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Confocal imaging in a fungal invasion of contact lenses

Indian Journal of Ophthalmology, 2020
Garvit Bhutani, Pravin K Vaddavalli
doaj   +1 more source

Multicentre study on inflammatory skin diseases from The International Confocal Working Group: specific confocal microscopy features and an algorithmic method of diagnosis

, 2016
Background: The real value of reflectance confocal microscopy (RCM) for the evaluation of inflammatory skin conditions remains unclear. A project on RCM for inflammatory skin diseases involving international centres was designed by a coordinating centre ...
Malvehy, J., Segura, Sonia, Gill, M., PELLACANI, Giovanni, Ardigo, M., Longo, C., LONGO, Caterina, Debarbieux, Sebastien, Kline, Mitchell, Puig, Susanna, Soyer, Peter, Stanganelli, Ignazio, Debarbieux, S., Di Stefani, A., Pellacani, G., Gonzalez, S., Menezes, N., Rao, B., Venturini, M., The International Confocal Working Group Inflammatory Skin Diseases Project, Hofmann Wellenhof, R., Agozzino, M., Moscarella, E., Soyer, P., Gill, Melissa, Kline, M., Segura, S., Ulrich, Martina, MOSCARELLA, ELVIRA, Gerittsen, M. J., Menezes, Nuno, Gerittsen, Marie-Jeanne, Gerittsen, Marie Jeanne, Puig, S., Rao, Babar, Malvehy, Joseph, Hofmann-Wellenhof, Rainer, Agozzino, Marina, Di Stefani, Alessandro, Ardigo, M, Ulrich, M., Hofmann Wellenhof, Rainer, Venturini, Marina   +42 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

The Role of RCM and LC-OCT in Genodermatoses Associated with Skin Cancer: A Narrative Review

Acta Dermato-Venereologica
Patients with genodermatoses, such as nevoid basal cell carcinoma syndrome, recessive dystrophic epidermolysis bullosa, familial atypical multiple mole and melanoma syndrome, xeroderma pigmentosum and ichthyosis with confetti, face a high risk of skin ...
Francesco Piscazzi, Cristina Carrera, Josep Riera-Monroig, Susana Puig, Josep Malvehy, Javiera Anker, Marco Ardigò   +6 more
doaj   +1 more source

Comparison of Confocal Microscopy and Scheimpflug Camera Findings in Avellino Corneal Dystrophy

, 2012
In this case report, a literature-guided comparative analysis of confocal microscopy and Scheimpflug camera findings of an adult with Avellino corneal dystrophy was performed.
Murat Küçükevcilioğlu, Fazıl Cüneyt Erdurman, Osman Melih Ceylan, Volkan Hürmeriç   +3 more
core   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source