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Confocal Raman Spectroscopy of Whole Hairs
Applied Spectroscopy, 2013This paper describes the application of Raman spectroscopy to whole hair fibers. Previously this has proved difficult because the hairs are relatively opaque, and spatial resolution diminishes with depth because of the change in refractive index. A solution is to couple confocal Raman with multivariate curve resolution (MCR) data analysis, which ...
Paul D A, Pudney +5 more
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MEMS-based portable confocal Raman spectroscopy rapid imaging system
Applied Optics, 2023Aiming at the miniaturization and rapid imaging requirements of a portable confocal Raman system, a MEMS-based portable confocal Raman spectroscopy rapid imaging method is proposed in this study. This method combines the dual 2D MEMS mirror scanning method and the grid-by-grid scanning method.
Guozhuo, Zhang +4 more
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A new paradigm in dermatopharmacokinetics – Confocal Raman spectroscopy
International Journal of Pharmaceutics, 2013Confocal Raman spectroscopy (CRS) is a novel approach which has been used to determine stratum corneum thickness and to profile endogenous skin components. However, the utility of this technique for probing drug disposition in vivo has not been explored to date.
R, Mateus +4 more
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On optical depth profiling using confocal Raman spectroscopy
Analytical and Bioanalytical Chemistry, 2009Until 2006 the performance of confocal Raman spectroscopy depth profiling was typically described and modeled through the application of geometrical optics, including refraction at the surface, to explain the degree of resolution and the precise form of the depth profile obtained from transparent and semicrystalline materials.
Freebody, N. A. +2 more
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Dual-Axes Confocal Microlens for Raman Spectroscopy
2009 IEEE 22nd International Conference on Micro Electro Mechanical Systems, 2009This paper presents a novel dual-axes scanning microlens for in vivo near infrared (NIR) Raman spectroscopy. In vivo Raman spectra of fibrosarcoma tumor skin and normal mouse skin measured from the microlens are reported. Out-of-plane (Z-axis) and transverse (X-axis) actuations are demonstrated using electrostatic and electromagnetic forces ...
C.P.B. Siu, H. Wang, H. Zeng, M. Chiao
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In Vivo Confocal Raman Spectroscopy of the Human Cornea
Cornea, 1999To investigate the feasibility of a confocal Raman spectroscopic technique for the noninvasive assessment of corneal hydration in vivo in two legally blind subjects.A laser beam (632.8 nm; 15 mJ) was maintained on the cornea by using a microscope objective lens (x25 magnification, NA = 0.5, f = 10 mm) both for focusing the incident light as well as ...
N J, Bauer, F, Hendrikse, W F, March
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Surface Analysis Using Confocal Raman Micro-Spectroscopy
2002Recent developments in instrumentation and the availability of several high quality commercial Raman microscopes have made Raman micro-spectroscopy an emerging tool for surface analysis. Specifically, confocal Raman micro-spectroscopy allows for near diffraction-limited spatial resolution, with the chemical and structural information of vibrational ...
C. Hyett +3 more
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Efficient Characterization for Protein Crystals Using Confocal Raman Spectroscopy
Applied Spectroscopy, 2007Confocal Raman spectroscopy was applied to the characterization of various states emerging in the screening of protein crystallization. Four main characterized states, namely single crystals, microcrystals, precipitates, and clear drops without solid materials, appear in a droplet for crystallization; the first three states should be critically ...
Kohki, Noda +4 more
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Dual wavelength optical tweezers for confocal Raman spectroscopy
Optics Communications, 2005We describe the use of dual optical tweezers to manipulate micron-size particles in and out of the focus of a confocal Raman microscope. One of the beams excites the Raman spectrum while the second tweezers improves the sensitivity of the technique and also allows for the manipulation of the environment of the trapped objects.
C.M. Creely, G.P. Singh, D. Petrov
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