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Miniaturisation of Raman spectroscopy systems: from benchtop to backpocket.

Lab Chip
Hardy M, Kanade PP, Buchan E, Goldberg Oppenheimer P, McPolin CPT, Bowman RM.   +5 more
europepmc   +1 more source

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A new paradigm in dermatopharmacokinetics – Confocal Raman spectroscopy

International Journal of Pharmaceutics, 2013
Confocal Raman spectroscopy (CRS) is a novel approach which has been used to determine stratum corneum thickness and to profile endogenous skin components. However, the utility of this technique for probing drug disposition in vivo has not been explored to date.
R Mateus, Jonathan Hadgraft, Majella E Lane   +2 more
exaly   +3 more sources

Imaging of the Ferroelectric Domain Structures by Confocal Raman Spectroscopy

Ferroelectrics, 2011
Confocal Raman spectroscopy was performed as an archetype imaging method to study the ferroelectric domain structure of periodically poled lithium niobate. More precisely, the linkage out of spatial resolution and spectral information proved itself as very useful.
Simone Sanna, W G Schmidt
exaly   +2 more sources

Efficient Characterization for Protein Crystals Using Confocal Raman Spectroscopy

Applied Spectroscopy, 2007
Confocal Raman spectroscopy was applied to the characterization of various states emerging in the screening of protein crystallization. Four main characterized states, namely single crystals, microcrystals, precipitates, and clear drops without solid materials, appear in a droplet for crystallization; the first three states should be critically ...
Shu Watanabe, Shigeyuki Yokoyama
exaly   +3 more sources

Confocal Raman Spectroscopy of Whole Hairs

Applied Spectroscopy, 2013
This paper describes the application of Raman spectroscopy to whole hair fibers. Previously this has proved difficult because the hairs are relatively opaque, and spatial resolution diminishes with depth because of the change in refractive index. A solution is to couple confocal Raman with multivariate curve resolution (MCR) data analysis, which ...
Paul D A, Pudney, Eleanor Y M, Bonnist, Kevin J, Mutch, Rachel, Nicholls, Hugh, Rieley, Samuel, Stanfield   +5 more
openaire   +2 more sources

In Vivo Confocal Raman Spectroscopy of the Human Cornea

Cornea, 1999
To investigate the feasibility of a confocal Raman spectroscopic technique for the noninvasive assessment of corneal hydration in vivo in two legally blind subjects.A laser beam (632.8 nm; 15 mJ) was maintained on the cornea by using a microscope objective lens (x25 magnification, NA = 0.5, f = 10 mm) both for focusing the incident light as well as ...
N J, Bauer, F, Hendrikse, W F, March
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On optical depth profiling using confocal Raman spectroscopy

Analytical and Bioanalytical Chemistry, 2009
Until 2006 the performance of confocal Raman spectroscopy depth profiling was typically described and modeled through the application of geometrical optics, including refraction at the surface, to explain the degree of resolution and the precise form of the depth profile obtained from transparent and semicrystalline materials.
Freebody, N. A., Vaughan, A. S., Macdonald, A. M.   +2 more
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Dual-Axes Confocal Microlens for Raman Spectroscopy

2009 IEEE 22nd International Conference on Micro Electro Mechanical Systems, 2009
This paper presents a novel dual-axes scanning microlens for in vivo near infrared (NIR) Raman spectroscopy. In vivo Raman spectra of fibrosarcoma tumor skin and normal mouse skin measured from the microlens are reported. Out-of-plane (Z-axis) and transverse (X-axis) actuations are demonstrated using electrostatic and electromagnetic forces ...
C.P.B. Siu, H. Wang, H. Zeng, M. Chiao
openaire   +1 more source