Results 31 to 40 of about 2,281 (262)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Overdetermined Systems, Conformal Differential Geometry, and the BGG Complex [PDF]

, 2008
This is an expanded version of a series of two lectures given at the IMA summer program “Symmetries and overdetermined systems of partial differential equations”. The main part of the article describes the Riemannian version of the prolongation procedure for certain overdetermined systems obtained recently in joint work with T.P. Branson, M.G. Eastwood,
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Q-Curvature, Spectral Invariants, and Representation Theory

Symmetry, Integrability and Geometry: Methods and Applications, 2007
We give an introductory account of functional determinants of elliptic operators on manifolds and Polyakov-type formulas for their infinitesimal and finite conformal variations.
Thomas P. Branson
doaj  

Geometric invariants properties of osculating curves under conformal transformation in Euclidean space ℝ3

Demonstratio Mathematica
An osculating curve is a type of curve in space that holds significance in the study of differential geometry. In this article, we investigate certain geometric invariants of osculating curves on smooth and regularly immersed surfaces under conformal ...
Singh Kuljeet, Sharma Sandeep, Lone Mohamd Saleem   +2 more
doaj   +1 more source

Geometric classification of 4d N=2 $$ \mathcal{N}=2 $$ SCFTs

Journal of High Energy Physics, 2018
The classification of 4d N=2 $$ \mathcal{N}=2 $$ SCFTs boils down to the classification of conical special geometries with closed Reeb orbits (CSG). Under mild assumptions, one shows that the underlying complex space of a CSG is (birational to) an affine
Matteo Caorsi, Sergio Cecotti
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Horizons that gyre and gimble: a differential characterization of null hypersurfaces

European Physical Journal C: Particles and Fields
Motivated by the thermodynamics of black hole solutions conformal to stationary solutions, we study the geometric invariant theory of null hypersurfaces.
Samuel Blitz, David McNutt
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

A superposition free method for protein conformational ensemble analyses and local clustering based on a differential geometry representation of backbone [PDF]

Proteins: Structure, Function, and Bioinformatics, 2019
Abstract Here a differential geometry (DG) representation of protein backbone is explored on the analyses of protein conformational ensembles. The protein backbone is described by curvature, κ, and torsion, τ, values per residue and we propose 1) a new dissimilarity and protein flexibility measurement and 2) a ...
Antonio Marinho da Silva Neto, Samuel Reghim Silva, Michele Vendruscolo, Carlo Camilloni, Rinaldo Wander Montalvão   +4 more
openaire   +2 more sources