Results 51 to 60 of about 22,282 (266)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Extensions of two-field mimetic gravity
Journal of High Energy Physics, 2023 Two-field mimetic gravity was recently realized by looking at the singular limit of the conformal transformation between the auxiliary metric and the physical metric with two scalar fields involved.
Yunlong Zheng, Haomin Rao
doaj +1 more source
Factorized lightcone expansion of conformal blocks [PDF]
Journal of High Energy Physics, 2021 Abstract We present a factorized decomposition of 4-point scalar conformal blocks near the lightcone, which applies to arbitrary intermediate spin and general spacetime dimensions. Then we discuss the systematic expansion in large intermediate spin and the resummations of the large-spin tails of Regge trajectories.
openaire +4 more sources
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Electronic Journal of Differential Equations, 2009 We investigate the existence of weak solutions to a class of quasilinear elliptic equations with nonlinear Neumann boundary conditions in exterior domains. Problems of this kind arise in various areas of science and technology. An important model case
Nicolae Tarfulea, Dumitru Motreanu
doaj
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Spontaneous Symmetry Breaking in 5D Conformally Invariant Gravity
Advances in High Energy Physics, 2016 We explore the possibility of the spontaneous symmetry breaking in 5D conformally invariant gravity, whose action consists of a scalar field nonminimally coupled to the curvature with its potential. Performing dimensional reduction via ADM decomposition,
Taeyoon Moon, Phillial Oh
doaj +1 more source
Analytical solutions of spherical structures with relativistic corrections
European Physical Journal C: Particles and Fields, 2023 This paper analyzes the characteristic of a non-static sphere along with anisotropic fluid distribution in the background of modified $$f(\mathcal {G})$$ f ( G ) theory.
M. Z. Bhatti +3 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source