The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Development of a methodology to describe udder conformation in sows
The aim of this study was to develop a methodology to measure sow udder conformation to use in studying the correlation between udder traits and piglet survival, health and performance.
A. Balzani, H.J. Cordell, S.A. Edwards
doaj +1 more source
Design Equation: A Novel Approach to Heteropolymer Design
A novel approach to heteropolymer design is proposed. It is based on the criterion by Kurosky and Deutsch, with which the probability of a target conformation in a conformation space is maximized at low but finite temperature.
\uSali A. +20 more
core +1 more source
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Carcass characteristics of small and medium-frame Aberdeen Angus young steers=Características da carcaça de novilhos super jovens Aberdeen Angus de biótipos pequeno e médio [PDF]
Carcass characteristics of small and medium-frame Aberdeen Angus young steers, finished in feedlot and slaughtered with similar subcutaneous fat thickness are evaluated.
Lucas Braido Pereira +5 more
doaj
Crystal structure of N-(propan-2-ylcarbamothioyl)benzamide
In the crystal structure of the title compound, C11H14N2OS, the six atoms of the central C2N2OS residue are coplanar (r.m.s. deviation = 0.002 Å), which facilitates the formation of an intramolecular N—H...O hydrogen bond, which closes an S(6) loop.
Jerry P. Jasinski +4 more
doaj +1 more source
Theory of Side-Chain Liquid Crystal Polymers: Bulk Behavior and Chain Conformation [PDF]
We study the thermodynamics and chain conformation of side-chain liquid crystal polymers (SCLCPs) in the bulk using the self-consistent-field approach and a new model to account for the coupling between the orientation of the side-chain liquid-crystal ...
Wang, Rui, Wang, Zhen-Gang
core
Multiplexed analysis of chromosome conformation at vastly improved sensitivity
Methods for analyzing chromosome conformation in mammalian cells are either low resolution or low throughput and are technically challenging. In next-generation (NG) Capture-C, we have redesigned the Capture-C method to achieve unprecedented levels of ...
James O. J. Davies +6 more
semanticscholar +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
cis-6-Methoxycarbonyl-2,10-dioxa-1-phosphabicyclo[4.4.0]decane 1-Oxide [PDF]
The crystal structure of the title compound, C9H1505P, is described. The molecule consists of two cis-fused six-membered rings, both in the chair conformation.
Bennett, Dennis W. +4 more
core +1 more source

