Results 71 to 80 of about 22,492,002 (302)

TS-Torquoselectivity from Global Conformational Profile [PDF]

, 2021
From global conformational profile and differential activation energies of conrotatory outward and inward ring openings of all the conformers, it is shown that (a) 3-OMe-cyclobutene must open exclusively outward, and (b) conformers exist for 3-CHO-, 3 ...
Arpita, Yadav, Maddali L N, Rao, Veejendra, Yadav   +2 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

conformational analysis

, 2014
Citation: 'conformational analysis' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.C01259 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Development of a normal mode-based geometric simulation approach for investigating the intrinsic mobility of proteins [PDF]

, 2010
Specific functions of biological systems often require conformational transitions of macromolecules. Thus, being able to describe and predict conformational changes of biological macromolecules is not only important for understanding their impact on ...
Ahmed, Aqeel
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Recent Trends in conformational Analysis.

, 2011
An outlook of the various research fields of organic chemistry where conformational analysis plays a fundamental role is presented. The section Methodologies for Conformational Analysis is focused on the information that can be obtained by various ...
D. Casarini, A. MAZZANTI, Daniele Casarini, CASARINI, Daniele, MAZZANTI, ANDREA, Andrea Mazzanti   +5 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Computational Pharmacodynamic Analysis of Cyclopeptides Derived from c[Trp-Phe-D-Pro-Phe] (CJ-15,208), an Unusual Class of Mixed μ/k-Opioid Receptor Ligands Lacking the Traditional Pharmacophores

Biomedicines
Background: There is currently increasing interest in atypical opioid compounds capable of expanding their clinical applications beyond pain management, including the treatment of psychiatric disorders and substance abuse.
Marco Francescato, Hang Liao, Lorenzo Cavina, Andrea Bedini, Luca Gentilucci   +4 more
doaj   +1 more source

Density functional theory (DFT) calculations of conformational energies and interconversion pathways in 1,2,7-thiadiazepane [PDF]

Journal of the Serbian Chemical Society, 2011
The molecular structure and conformational analysis of 1,2,7-thiadiazapane conformers were investigated by density functional theory (DFT) calculations at the B3LYP/cc-pVDZ level of theory.
MINA HAGHDADI, NAHID FAROKHI
doaj