Results 1 to 10 of about 3,678,223 (192)
Integrin Conformational Dynamics and Mechanotransduction
Cells, 2022 The function of the integrin family of receptors as central mediators of cell-extracellular matrix (ECM) and cell–cell adhesion requires a remarkable convergence of interactions and influences.
Reza Kolasangiani +2 more
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Scientific Reports, 2021 G protein-coupled receptors (GPCRs) are the largest class of transmembrane proteins, making them an important target for therapeutics. Activation of these receptors is modulated by orthosteric ligands, which stabilize one or several states within a ...
Dennis D. Fernandes +10 more
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Dynamozones are the most obvious sign of the evolution of conformational dynamics in HIV-1 protease
Scientific Reports, 2023 Proteins are not static but are flexible molecules that can adopt many different conformations. The HIV-1 protease is an important target for the development of therapies to treat AIDS, due to its critical role in the viral life cycle.
Mohammad Rahimi +2 more
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Conformational Dynamics of a Single Protein Monitored for 24 h at Video Rate [PDF]
Nano letters (Print), 2018 We use plasmon rulers to follow the conformational dynamics of a single protein for up to 24 h at a video rate. The plasmon ruler consists of two gold nanospheres connected by a single protein linker.
Weixiang Ye +10 more
semanticscholar +6 more sources
eLife, 2019 Metabotropic glutamate receptors (mGluRs) are class C, synaptic G-protein-coupled receptors (GPCRs) that contain large extracellular ligand binding domains (LBDs) and form constitutive dimers.
Vanessa A Gutzeit +6 more
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Visualizing conformational dynamics of proteins in solution and at the cell membrane
eLife, 2018 Conformational dynamics underlie enzyme function, yet are generally inaccessible via traditional structural approaches. FRET has the potential to measure conformational dynamics in vitro and in intact cells, but technical barriers have thus far limited ...
Sharona E Gordon +2 more
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Nuclear magnetic resonance free ligand conformations and atomic resolution dynamics [PDF]
Magnetic Resonance, 2021 Knowledge of free ligand conformational preferences (energy minima) and conformational dynamics (rotational energy barriers) of small molecules in solution can guide drug design hypotheses and help rank ideas to bias syntheses towards more active ...
A. Y. S. Balazs +4 more
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Chemical Reviews, 2022 Motions in biomolecules are critical for biochemical reactions. In cells, many biochemical reactions are executed inside of biomolecular condensates formed by ultradynamic intrinsically disordered proteins.
A. Abyzov +2 more
semanticscholar +1 more source
Biophysica, 2022 Single-molecule Förster resonance energy transfer (smFRET) enables the deconvolution of various conformational substates of biomolecules. Over the past two decades, it has been widely used to understand the conformational dynamics of enzymes.
Mai Huynh, Bhaswati Sengupta
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Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike
eLife, 2022 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects cells through binding to angiotensin-converting enzyme 2 (ACE2). This interaction is mediated by the receptor-binding domain (RBD) of the viral spike (S) glycoprotein.
M. A. Díaz-Salinas +7 more
semanticscholar +1 more source