Results 81 to 90 of about 3,678,372 (337)
Molecular Computing: from conformational pattern recognition to complex processing networks
, 1996 Natural biomolecular systems process information in a radically different manner than programmable machines. Conformational interactions, the basis of specificity and self-assembly, are of key importance.
Conrad, Michael, Zauner, Klaus-Peter
core +1 more source
Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating [PDF]
, 2011 We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal ...
Markhasin, V. S. +3 more
core +3 more sources
Iterated conformal dynamics and Laplacian growth [PDF]
Physical Review E, 2002 The method of iterated conformal maps for the study of Diffusion Limited Aggregates (DLA) is generalized to the study of Laplacian Growth Patterns and related processes. We emphasize the fundamental difference between these processes: DLA is grown serially with constant size particles, while Laplacian patterns are grown by advancing each boundary point
Barra, Felipe +2 more
openaire +4 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Small StructuresThe dynamics of excited‐state charge transfer (CT) in second near‐infrared (NIR‐II) fluorophore proceeds with conformational change that govern fluorescence.
Minghui Li +11 more
doaj +1 more source
Integrating Experiment and Theory to Understand TCR-pMHC Dynamics
Frontiers in Immunology, 2018 The conformational dynamism of proteins is well established. Rather than having a single structure, proteins are more accurately described as a conformational ensemble that exists across a rugged energy landscape, where different conformational sub ...
Ashley M. Buckle, Natalie A. Borg
doaj +1 more source
Molecular dynamics simulation of the follicle-stimulating hormone receptor. Understanding the conformational dynamics of receptor variants at positions N680 and D408 from in silico analysis. [PDF]
PLoS ONE, 2018 Follicle-stimulating hormone receptor (FSHR) is a G-protein coupled receptor (GPCR) and a prototype of the glycoprotein hormone receptors subfamily of GPCRs.
Eduardo Jardón-Valadez +5 more
doaj +1 more source
Structural Dynamics of Free Proteins in Diffraction [PDF]
, 2011 Among the macromolecular patterns of biological significance, right-handed α-helices are perhaps the most abundant structural motifs. Here, guided by experimental findings, we discuss both ultrafast initial steps and longer-time-scale structural dynamics
Lin, Milo M. +2 more
core +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
A variational conformational dynamics approach to the selection of collective variables in metadynamics. [PDF]
Journal of Chemical Physics, 2017 In this paper, we combine two powerful computational techniques, well-tempered metadynamics and time-lagged independent component analysis. The aim is to develop a new tool for studying rare events and exploring complex free energy landscapes ...
J. McCarty, M. Parrinello
semanticscholar +1 more source