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Twisted Nanographenes with Robust Conformational Stability [PDF]
NanomaterialsOwing to a lack of methodology for rationally and selectively synthesizing twisted nanographenes, it is usually inevitable that we obtain nanographenes as a mixture with various geometries, such as unidirectionally twisted, alternatively twisted ...
Penghui Song +2 more
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Conformational Stability of the N-Terminal Region of MDM2 [PDF]
Molecules, 2023 MDM2 is an E3 ubiquitin ligase which is crucial for the degradation and inhibition of the key tumor-suppressor protein p53. In this work, we explored the stability and the conformational features of the N-terminal region of MDM2 (N-MDM2), through which ...
Bruno Rizzuti +3 more
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Islands of conformational stability for filopodia. [PDF]
PLoS ONE, 2013 Filopodia are long, thin protrusions formed when bundles of fibers grow outwardly from a cell surface while remaining closed in a membrane tube.
D Robert Daniels, Matthew S Turner
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Effect of Sodium Valproate on the Conformational Stability of the Visual G Protein-Coupled Receptor Rhodopsin [PDF]
Molecules, 2021 Rhodopsin is the G protein-coupled receptor of rod photoreceptor cells that mediates vertebrate vision at low light intensities. Mutations in rhodopsin cause inherited retinal degenerative diseases such as retinitis pigmentosa.
Neda Razzaghi +5 more
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Conformational stability of SARS-CoV-2 glycoprotein spike variants [PDF]
iScience, 2023 Summary: The severe acute respiratory syndrome spread worldwide, causing a pandemic. SARS-CoV-2 mutations have arisen in the spike, a glycoprotein at the viral envelope and an antigenic candidate for vaccines against COVID-19.
Hiam R.S. Arruda +14 more
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Conformational Stability Effect of Polymeric Iron Chelators [PDF]
iScience, 2019 Summary: The design and synthesis of metal chelators with extraordinary metal affinities is a basic and challenging scientific problem of both fundamental and practical importance.
Jian Qian, Cory Berkland
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Some Clues about Enzymes from Psychrophilic Microorganisms
Microorganisms, 2022 Enzymes purified from psychrophilic microorganisms prove to be efficient catalysts at low temperatures and possess a great potential for biotechnological applications.
Roberta Rapuano, Giuseppe Graziano
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The residues 4 to 6 at the N-terminus in particular modulate fibril propagation of β2-microglobulin
Acta Biochimica et Biophysica Sinica, 2021 The ΔN6 truncation is the main posttranslational modification of β2-microglobulin (β2M) found in dialysis-related amyloid. Investigation of the interaction of wild-type (WT) β2M with N-terminally truncated variants is therefore of medical relevance ...
Dang Haibin +9 more
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Targeting ErbB3 Receptor in Cancer with Inhibitory Antibodies from Llama
Biomedicines, 2021 The human ErbB3 receptor confers resistance to the pharmacological inhibition of EGFR and HER2 receptor tyrosine kinases in cancer, which makes it an important therapeutic target.
Igor E. Eliseev +9 more
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Conformational stability of apoflavodoxin [PDF]
Protein Science, 1996 AbstractFlavodoxins areα/βproteins that mediate electron transfer reactions. The conformational stability of apoflavodoxin fromAnabœnaPCC 7119 has been studied by calorimetry and urea denaturation as a function of pH and ionic strength. At pH > 12, the protein is unfolded. Between pH 11 and pH 6, the apoprotein is folded properly as judged from near‐
C G, Genzor +5 more
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