Results 11 to 20 of about 181,206 (262)
Foods, 2023 The aim of this study was to employ molecular dynamics simulations to elucidate the mechanism involved in amylose–zein complexation and the stability of the molecular conformation of amylose–zein complexes in water at the atomic and molecular levels. The
Chaofan Wang +6 more
doaj +1 more source
General Counteraction Exerted by Sugars against Denaturants
Life, 2021 The conformational stability of globular proteins is strongly influenced by the addition to water of different co-solutes. Some of the latter destabilize the native state, while others stabilize it.
Serena Cozzolino +3 more
doaj +1 more source
Temperature and pH-Dependent Behaviors of mAb Drugs: A Case Study for Trastuzumab
Scientia Pharmaceutica, 2022 The distortions in the high-order structure of therapeutic monoclonal antibodies (mAbs) under different environmental conditions acutely affect mAb stability, resulting in altered safety, efficacy, and shelf-life profiles.
Fatma Sert +6 more
doaj +1 more source
Conformational stability of the myosin rod [PDF]
European Journal of Biochemistry, 1984 Chymotryptic cleavage patterns of myosin rods from pig stomach, chicken gizzard, and rabbit skeletal muscle indicate that short (∼45 nm) heavy meromyosin subfragment 2 (SF2) is a consistent product of all three rods, whereas long (∼ 60 nm) SF2 is derived only from skeletal muscle myosin.Differential scanning calorimetry was used to follow the thermally
R A, Cross +4 more
openaire +2 more sources
Biochemical Characterization of Prion Strains in Bank Voles
Pathogens, 2013 Prions exist as different strains exhibiting distinct disease phenotypes. Currently, the identification of prion strains is still based on biological strain typing in rodents.
Romolo Nonno +5 more
doaj +1 more source
The Conformational Stabilities of Tropomyosins [PDF]
Australian Journal of Biological Sciences, 1976 The stability to denaturation by heat and guanidine hydrochloride of seven vertebrate (including skeletal, cardiac and smooth muscle) tropomyosins and three invertebrate tropomyosins was examined. The transition profiles were discontinuous and in many cases distinct plateaux were observed which indicated the presence of unique partially unfolded states
openaire +2 more sources
Phosphorylation Stabilizes the Active Conformation of Rhodopsin [PDF]
Biochemistry, 1998 Deactivation of many G protein coupled receptors (GPCRs) is now known to require phosphorylation of the activated receptor. The first such GPCR so analyzed was rhodopsin, which upon light activation forms an intramolecular equilibrium between the two conformers, metarhodopsin I and II (MI and MII).
, Gibson, , Parkes, , Liebman
openaire +3 more sources
An in Silico Approach to Reveal the Nanodisc Formulation of Doxorubicin
Frontiers in Bioengineering and Biotechnology, 2022 Molecular dynamic behaviors of nanodisc (ND) formulations of free doxorubicin (DOX) and DOX conjugated lipid prodrug molecules were investigated by molecular dynamics (MD) simulations.
Daiyun Xu +14 more
doaj +1 more source
Stability theorems for conformal foliations [PDF]
Proceedings of the American Mathematical Society, 1984 The global stability theorem of G. Reeb is no longer true if the codimension of the foliation is greater than one. However, in the presence of a complete transverse Riemannian structure, B. Reinhart obtained a global stability result. We prove global stability theorems for the much larger class of conformal foliations.
openaire +2 more sources
Signatures of Conformational Stability and Oxidation Resistance in Proteomes of Pathogenic Bacteria
Cell Reports, 2014 Protein oxidation is known to compromise vital cellular functions. Therefore, invading pathogenic bacteria must resist damage inflicted by host defenses via reactive oxygen species.
Anita Vidovic +3 more
doaj +1 more source