Results 21 to 30 of about 181,206 (262)

On the Stability of Minimal Submanifolds in Conformal Spheres

The Journal of Geometric Analysis, 2023
AbstractGiven an n-dimensional Riemannian sphere conformal to the round one and $$\delta $$ δ -pinched, we show that it does not contain any closed stable minimal submanifold of dimension $$2\le k\le n-\delta ^{-1}$$ 2 ≤ k
Giada Franz, Federico Trinca
openaire   +6 more sources

Computational and Experimental Evaluation of the Stability of a GLP-1-like Peptide in Ethanol–Water Mixtures

Pharmaceutics, 2022
Aggregation resulting from the self-association of peptide molecules remains a major challenge during preformulation. Whereas certain organic solvents are known to promote aggregation, ethanol (EtOH) is capable of disrupting interactions between peptide ...
Lok Hin Lui, Raphael Egbu, Thomas Graver, Gareth R. Williams, Steve Brocchini, Ajoy Velayudhan   +5 more
doaj   +1 more source

Biophysical Properties and Cytotoxicity of Feruloylated Helix Lucorum Hemocyanin

Acta Chimica Slovenica, 2020
For the first time Helix lucorum hemocyanin (HlH) has been feruloylated. Two HlH conjugates with 40- and 120- ferulic acid residues were prepared, denoted as FA-HlH-1 and FA-HlH-2.
Maya Guncheva, Krassimira Idakieva, Svetla Todinova, Elena Stoyanova, Denitsa Yancheva   +4 more
doaj   +1 more source

Functional rescue of F508del-CFTR using small molecule correctors

Frontiers in Pharmacology, 2012
High-throughput screens for small molecules that are effective in correcting the functional expression of F508del-CFTR have yielded several promising hits. Two such compounds are currently in clinical trial.
Steven eMolinski, Paul DW Eckford, Stan ePasyk, Saumel eAhmadi, Stephanie eChin, Christine E. Bear   +5 more
doaj   +1 more source

Protein folding modulates the swapped dimerization mechanism of methyl-accepting chemotaxis heme sensors. [PDF]

PLoS ONE, 2012
The periplasmic sensor domains GSU0582 and GSU0935 are part of methyl accepting chemotaxis proteins in the bacterium Geobacter sulfurreducens. Both contain one c-type heme group and their crystal structures revealed that these domains form swapped dimers
Marta A Silva, Tânia G Lucas, Carlos A Salgueiro, Cláudio M Gomes   +3 more
doaj   +1 more source

Ribosomal accretion, apriorism and the phylogenetic method: A response to Petrov and Williams

Frontiers in Genetics, 2015
Historical (ideographic) and non-historical (nomothetic) studies of ribosomal accretion appear to arrive at diametrically opposite conclusions. Phylogenetic analysis of thousands of RNA molecules and protein structures in hundreds of genomes supports the
Derek eCaetano-Anollés, Gustavo eCaetano-Anollés   +1 more
doaj   +1 more source

Investigation of the pH-dependent aggregation mechanisms of GCSF using low resolution protein characterization techniques and advanced molecular dynamics simulations

Computational and Structural Biotechnology Journal, 2022
Granulocyte-colony stimulating factor (GCSF) is a widely used therapeutic protein to treat neutropenia. GCSF has an increased propensity to aggregate if the pH is increased above 5.0.
Suk Kyu Ko, Carolin Berner, Alina Kulakova, Markus Schneider, Iris Antes, Gerhard Winter, Pernille Harris, Günther H.J. Peters   +7 more
doaj   +1 more source

Development of Antibody Arrays for Monoclonal Antibody Higher Order Structure Analysis

Frontiers in Pharmacology, 2013
Antibody arrays were developed to probe a monoclonal antibody’s three-dimensional structure (3-D structure). Peptides with overlapping regions were designed to cover the whole mAb light chain and heavy chain respectively and used to generate polyclonal ...
Xing eWang, Qing eLi, Michael eDavies
doaj   +1 more source

Delicate balance among thermal stability, binding affinity, and conformational space explored by single-domain VHH antibodies

Scientific Reports, 2021
The high binding affinities and specificities of antibodies have led to their use as drugs and biosensors. Single-domain VHH antibodies exhibit high specificity and affinity but have higher stability and solubility than conventional antibodies as they ...
Emina Ikeuchi, Daisuke Kuroda, Makoto Nakakido, Akikazu Murakami, Kouhei Tsumoto   +4 more
doaj   +1 more source

Stability Under Different Stress Treatments of a Virus-like Particle Vaccine Based on a Recombinant Hepatitis E Vaccine

Pharmaceuticals
Background/Objectives: Virus-like particles (VLPs) are effective vaccine platforms but are susceptible to degradation, which compromises stability and immunogenicity. A key challenge is the lack of sensitive early indicators of instability.
Zhiyun Qi, Sha Guo, Hanhan Li, Xijie Xia, Shuangshuang Qi, Enlian Tang, Zhenhao Zhou, Yiping Wang, Chuanfei Yu, Xing Wu, Hao Wu   +10 more
doaj   +1 more source