Results 101 to 110 of about 1,031,416 (263)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Estimating Mann–Whitney-Type Causal Effects for Right-Censored Survival Outcomes

Journal of Causal Inference, 2019
Mann–Whitney-type causal effects are clinically relevant, easy to interpret, and readily applicable to a wide range of study settings. This article considers estimation of such effects when the outcome variable is a survival time subject to right ...
Zhang Zhiwei, Liu Chunling, Ma Shujie, Zhang Min   +3 more
doaj   +1 more source

Quantifying confounding

, 2009
In observational studies on causal associations, comparison groups (e.g. groups of treated and untreated subjects) are likely to differ on prognostic characteristics.
Groenwold, R.H.H., Hak, E., Hoes, Arno, JC onderzoeksprogramma Methodology, Epidemiology & Health Economics   +4 more
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Statistical approaches in ambispective cohort studies: Challenges and methodological insights

Perspectives in Clinical Research
Ambispective cohort studies combine retrospective and prospective data collection to provide a comprehensive understanding of treatment outcomes over time.
Pattabhi Ramayya Machiraju, Gomathi Priya Jeyapal   +1 more
doaj   +1 more source

Do working conditions explain the increased risks of disability pension among men and women with low education? A follow-up of Swedish cohorts

Scandinavian Journal of Work, Environment & Health, 2014
OBJECTIVES: Rates of disability pension are greatly increased among people with low education. This study examines the extent to which associations between education and disability pensions might be explained by differences in working conditions ...
Daniel Falkstedt, Mona Backhans, Andreas Lundin, Peter Allebeck, Tomas Hemmingsson   +4 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Retrospective studies in emergency medicine: A practical guide to study design, bias, confounding, and interpretation

Turkish Journal of Emergency Medicine
Retrospective observational studies are a cornerstone of emergency medicine research, offering practical ways to address important clinical questions using real-world data.
Suha Turkmen, Sinan Pasli
doaj   +1 more source

Results after adjusting for potential confounding factors.

, 2012
Results after adjusting for potential confounding factors.
Shuo Wu (116238), Yanxun Liu (116240), Zhenxin Zhu (116236), Haiyan Lin (116227), Dongzhi Zhang (116230), Yongyuan Zhang (116233), Wenjia Meng (116221), Xiaowei Yang (116246), Chengqi Zhang (116222), Fuzhong Xue (116249), Fang Tang (116243), Qian Zhang (49333), Xinhong Song (116224)   +12 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source