Results 81 to 90 of about 1,031,416 (263)

Adaptability of High Dimensional Propensity Score Procedure in the Transition from ICD-9 to ICD-10 in the US Healthcare System

Clinical Epidemiology, 2023
Amir Sarayani,1,2 Joshua D Brown,1,2 Christian Hampp,1,3 William T Donahoo,4,5 Almut G Winterstein1,2 1Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL, USA; 2Center for Drug Safety and ...
Sarayani A, Brown JD, Hampp C, Donahoo WT, Winterstein AG   +4 more
doaj  

Causal Diagrams: Pitfalls and Tips

Journal of Epidemiology, 2020
Graphical models are useful tools in causal inference, and causal directed acyclic graphs (DAGs) are used extensively to determine the variables for which it is sufficient to control for confounding to estimate causal effects.
Etsuji Suzuki, Tomohiro Shinozaki, Eiji Yamamoto   +2 more
doaj   +1 more source

Curr Epidemiol Rep [PDF]

Purpose of review:Violence prevention research has enhanced our understanding of individual and community risk and protective factors for aggression and violence.

core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Methodological Tutorial Series for Epidemiological Studies: Confounder Selection and Sensitivity Analyses to Unmeasured Confounding From Epidemiological and Statistical Perspectives

Journal of Epidemiology
In observational studies, identifying and adjusting for a sufficient set of confounders is crucial for accurately estimating the causal effect of the exposure on the outcome.
Kosuke Inoue, Kentaro Sakamaki, Sho Komukai, Yuri Ito, Atsushi Goto, Tomohiro Shinozaki   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Are the effects of psychosocial exposures attributable to confounding? Evidence from a prospective observational study on psychological stress and mortality [PDF]

, 2001
<b>STUDY OBJECTIVES</b> To examine the association between perceived psychological stress and cause specific mortality in a population where perceived stress was not associated with material disadvantage.
Hart, C., Macleod, John, Heslop, P., Metcalfe, C, Hart, C, Heslop, P, Metcalfe, CR, Davey Smith, G., Carroll, Douglas, Davey Smith, G, Metcalfe, C., Carroll, D., Macleod, J., Macleod, JAA, Carroll, D   +14 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source