Results 71 to 80 of about 1,001,591 (299)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Frontiers in MedicineIntroductionThis study aims to discuss and assess the impact of three prevalent methodological biases: competing risks, immortal-time bias, and confounding bias in real-world observational studies evaluating treatment effectiveness.
Oksana Martinuka +11 more
doaj +1 more source
Transparent and complete reporting of confounding in observational research
JCPP Advances, 2022 Improved understanding of causal risk factors for child and adolescent mental health problems are dependent on observational research. Although confounding is a major limitation of observational research, this problem is widely ignored in the reporting ...
Henrik Larsson
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, 2009 In observational studies on causal associations, comparison groups (e.g. groups of treated and untreated subjects) are likely to differ on prognostic characteristics.
Groenwold, R.H.H.
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Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
This paper deals both with the issues of confounding and of control, as the definition of a confounding factor is far from universal and there exist different methodological approaches, ex ante and ex post, for controlling for a confounding factor.
Guillaume Wunsch
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Removal of ineligible outcome cases reduces confounding
, 2018 Alexander M Walker,1 Sebastian Schneeweiss,2 Maral DerSarkissian,3 Mei Sheng Duh4 1World Health Information Science Consultants, Newton, MA, USA; 2Division of Pharmacoepidemiology, Department of Medicine, Brigham & Women’s Hospital and Harvard ...
Schneeweiss S +3 more
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