Results 91 to 100 of about 8,216,381 (305)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Univariate and multivariate regression for detecting confounding factors.

, 2019
Univariate and multivariate regression for detecting confounding factors.
Dan Liao (288562), Liang Ma (37793), Ping Fu (273326), Jing Liu (38537)   +3 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A Review of Mendelian Randomization: Assumptions, Methods, and Application to Obesity-Related Diseases

Journal of Obesity & Metabolic Syndrome
Mendelian randomization (MR) is a statistical method that uses genetic variants as instrumental variables to estimate the causal effect of exposure on an outcome in the presence of unmeasured confounding.
Seungjae Lee, Woojoo Lee
doaj   +1 more source

Iron overload and arrhythmias: Influence of confounding factors

Journal of Arrhythmia, 2019
Arrhythmias as a cardiac complication of iron overload (IO) have been well described for decades in the clinical literature. They are assumed to be directly associated with the myocardial accumulation of iron.
Yukitaka Shizukuda, Douglas R. Rosing
doaj   +1 more source

Conditioning-induced cardioprotection: Aging as a confounding factor

The Korean Journal of Physiology & Pharmacology, 2018
The aging process induces a plethora of changes in the body including alterations in hormonal regulation and metabolism in various organs including the heart. Aging is associated with marked increase in the vulnerability of the heart to ischemia-reperfusion injury.
Randhawa, Puneet Kaur, Bali, Anjana, Virdi, Jasleen Kaur, Jaggi, Amteshwar Singh   +3 more
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Soil Chemistry Factors Confounding Crop Salinity Tolerance—A Review

Agronomy, 2016
The yield response of various crops to salinity under field conditions is affected by soil processes and environmental conditions. The composition of dissolved ions depend on soil chemical processes such as cation or anion exchange, oxidation-reduction ...
Pichu Rengasamy
doaj   +1 more source

Curr Epidemiol Rep [PDF]

Purpose of review:Violence prevention research has enhanced our understanding of individual and community risk and protective factors for aggression and violence.

core  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source