Results 71 to 80 of about 762,252 (305)

Association between air pollution and suicide: a time series analysis in four Colombian cities

Environmental Health, 2018
Background Recent epidemiological studies have suggested that air pollution could be associated with suicide. However, other studies have criticized these results for being analytically weak and not taking into account potential confounding factors.
Julián Alfredo Fernández-Niño, Claudia Iveth Astudillo-García, Laura Andrea Rodríguez-Villamizar, Víctor Alfonso Florez-Garcia   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

phMRI: methodological considerations for mitigating potential confounding factors

Frontiers in Neuroscience, 2015
Pharmacological Magnetic Resonance Imaging (phMRI) is a variant of conventional MRI that adds pharmacological manipulations in order to study the effects of drugs, or uses pharmacological probes to investigate basic or applied (e.g.
Julius H Bourke, Matthew B Wall, Matthew B Wall   +2 more
doaj   +1 more source

Accurate modeling of confounding variation in eQTL studies leads to a great increase in power to detect trans-regulatory effects

, 2011
Expression quantitative trait loci (eQTL) studies are an integral tool to investigate the genetic component of gene expression variation. A major challenge in the analysis of such studies are hidden confounding factors, such as unobserved covariates or ...
Neil Lawrence, Oliver Stegle, Nicolo Fusi   +2 more
core  

Univariate and multivariate regression for detecting confounding factors.

, 2019
Univariate and multivariate regression for detecting confounding factors.
Dan Liao (288562), Liang Ma (37793), Ping Fu (273326), Jing Liu (38537)   +3 more
core   +1 more source

Confounding Factors in the Transcriptome Analysis of an In-Vivo Exposure Experiment. [PDF]

, 2016
CONFOUNDING FACTORS:In transcriptomics experimentation, confounding factors frequently exist alongside the intended experimental factors and can severely influence the outcome of a transcriptome analysis.
Annemieke de Vries, Timo M Breit, de Vries, A, Wackers, P.F.K., Paul F K Wackers, Oskar Bruning (563285), Timo M. Breit (125461), Wendy Rodenburg, Wim A. Ensink (563289), Wim A Ensink, Wendy Rodenburg (44995), Han Rauwerda, Conny van Oostrom (274329), Annemieke de Vries (224578), Ensink, W.A., Conny van Oostrom, Rodenburg, W., Rauwerda, H., Jonker, M.J., Paul F. K. Wackers (847126), Dekker, R.J., Martijs J. Jonker (125464), van Oostrom, C., Rob J. Dekker (563287), Breit, T.M., Bruning, O., Han Rauwerda (563288), Rob J Dekker, Oskar Bruning, Martijs J Jonker   +29 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The correlation coefficient between Δtemp and possible confounding factors.

, 2019
The correlation coefficient between Δtemp and possible confounding factors.
Mami Matsushita (7310045), Yaeko Kawaguchi (7310057), Akiko Suganuma (7310054), Naoki Sakane (208970), Shinsuke Nirengi (7310042), Hitoshi Wakabayashi (3062946), Masayuki Saito (205833), Masayuki Domichi (7310048), Shin Sukino (7310051), Shinichi Suzuki (324227), Takeshi Hashimoto (69561)   +10 more
core   +1 more source

Outlier detection for foot complaint diagnosis : modeling confounding factors using metric learning [PDF]

, 2020
: Diagnosing foot complaints using plantar pressure videos is complicated by the presence of confounding factors (e.g. age, weight). Outlier detection could help with diagnosis, but these confounding factors result in data that is not independent and ...
Booth, Brian, Keijsers, Noel L. W., Sijbers, Jan, Brian G. Booth, Keijsers, Noel L.W., Noel L. W. Keijsers, Jan Sijbers   +6 more
core   +1 more source