Results 51 to 60 of about 5,897 (164)

Pancreatic Islet Cell Hormones: Secretion, Function, and Diabetes Therapy

MedComm, Volume 6, Issue 9, September 2025.
The pancreatic islets, composed of α, β, δ, ε, and PP cells, play a central role in maintaining glucose homeostasis. This review examines the mechanisms of islet hormone secretion and their functional crosstalk networks, alongside the pathophysiology of diabetes driven by hormonal dysregulation.
Jinfang Ma, Mao Li, Lingxiao Yang, Qingxing Xie, Rongping Fan, Xi Lu, Xing Huang, Nanwei Tong, Zhenyu Duan   +8 more
wiley   +1 more source

Cardiomyopathy in Offspring of Pregestational Diabetic Mouse Pregnancy [PDF]

, 2014
Purpose. To investigate cardiomyopathy in offspring in a mouse model of pregestational type 1 diabetic pregnancy. Methods. Pregestational diabetes was induced with STZ administration in female C57BL6/J mice that were subsequently mated with healthy ...
Baugh, John, Corrigan, Niamh, Dowling, Daniel, Downey, Paul, Horgan, Stephen, McAuliffe, Fionnuala M, Watson, Chris J   +6 more
core   +3 more sources

Sex‐specific white matter alterations in children exposed to high pregestational BMI

Obesity, Volume 33, Issue 6, Page 1113-1125, June 2025.
Abstract Objective This study investigated whether exposure to high pregestational BMI (≥ 25 kg/m2) is associated with alterations in white matter microstructure in early childhood, explored sex‐specific effects, and examined associations with cognitive performance. Methods A total of 90 children from the Alberta Pregnancy Outcomes and Nutrition (APrON)
Samson Nivins, Jess Reynolds, Gerald F. Giesbrecht, Deborah Dewey, Nicole Letourneau, Catherine Lebel   +5 more
wiley   +1 more source

State of the Art and Consensus Statements by Healthcare Providers, Patients, and Caregivers on Continuous Glucose Monitoring in Liver Glycogen Storage Diseases

Journal of Inherited Metabolic Disease, Volume 48, Issue 3, May 2025.
ABSTRACT Continuous glucose monitoring (CGM) is increasingly used although not officially registered for the management of people living with liver glycogen storage diseases (GSDs). The aims of this study were twofold: (a) to investigate the current experiences of healthcare providers (HCPs), patients, and caregivers using CGM to monitor glucose ...
Terry G. J. Derks, Ruben J. Overduin, Sarah C. Grünert, Alessandro Rossi, CGM GSD Collaborators Group, Terry G. J. Derks, Ruben J. Overduin, Bibiana M. de Oliveira, Julien H. Park, David Weinstein, Diva D. De Leon, Yuval E. Landau, Alessandro La Rosa, Damian Cohen, Anke Schumann, Anne Kwok Mei Kwun, Yunkoo Kang, Foekje de Boer, María Clemente, Wendy E. Smith, Margo Sheck Breilyn, Rebecca Riba‐Wolman, Karen Loechner, Malaya Mount, John Mitchell, Samantha Vergano, Stefanie Rosenbaum‐Fabian, Shaylee King, Iris Ferrecchia, Kaustuv Bhattacharya, David F. Rodriguez‐Buritica, Katalin Ross, Anastasia Skouma, Allan M. Lund, Elizabeth Robinson, Caitie Hessenthaler, Emma Corcoran, Tassia Tonon, Daniela Karall, Laura Sliwoski, Ulrike Steuerwald, Patricia Pérez Mohand, Julieta Bonvin Sallago, Nerea López Maldonado, Renee Bethel, Monica Boyer, Timothy Fazio, Vincenza Gragnaniello, María‐Luz Couce, Chiara Falanga, Urh Groselj, Brandy Rawls‐Castillo, Zazil Olivares‐Sandoval, Carolina F. Moura de Souza, Sabine Scholl‐Buergi, Annalisa Madeo, Julia B. Hennermann, Eva Venegas, Arianna Maiorana, Dorothea Haas, Benjamin Weil, Eva Thimm, Alboren Shtylla, Thomas Opladen, Thomas Scherer, Danielle K. Bourque, Tergita Preci, Michel Hochuli, Thomas Casswall, Ellen Crushell, Shagun Kaur, Petra Zsidegh, Risto Lapatto, Matthias Gautschi, Dorothea Möslinger, Peter Witters, Ute Stachelhaus‐Theimer, Flannery Tomberlin, Ana Drole Torkar, Elena Procopio, Luisa Diogo Matos, Saskia Wortmann, Julia Neugebauer, Teresa Rink, Natalie Weinhold, Suresh Vijay, Krista Engen, Jean‐Marc Nuoffer, Andrea Haijer‐Schreuder, Peter Freisinger, Monika Williams, Patricia Janeiro, Justė Parnarauskienė, Çiğdem Seher Kasapkara, Miguel Angel Martinez Olmos, Areeg El‐Gharbawy, Heather Saavedra, Nicola Longo, Magali Reyes Apodaca, Sunita Bijarnia‐Mahay, Leyla Tümer, Martina Huemer, René Santer, Lina Ghaloul‐Gonzalez, Katherine Anderson, Rebecca L. Koch, Christian Kogelmann, Annamaria Sapuppo, Brian Shayota, Melanie M. van der Klauw, Fatih Ezgu, Clemens Kamrath, Camilla Carøe, Karolina M. Stepien, Fiona White, Sarah C. Grünert, Alessandro Rossi   +116 more
wiley   +1 more source

Maternal serum zinc and copper and infant birth weight [PDF]

Objective: Trace element deficiencies have been documented to play an important role in determination of the fetal outcome. It has been reported that the pregnant women in developing countries consume diets with a lower density of minerals and vitamins ...
انتشاری مقدم, افسانه, سعادتی, حکیمه, شاهی زاده, صحیفه, عیسی زاده فر, خاطره, مأذنی, محمد, میرزا رحیمی, مهرداد   +5 more
core  

Erythematous Papules and Plaques in an Infant Receiving Glucagon Therapy

JEADV Clinical Practice, Volume 4, Issue 5, Page 1263-1266, December 2025.
Sara Al Janahi, Alya Al‐Ali, Meera Al Adawi, Yusra S. Al Ali, Harish Bangalore   +4 more
wiley   +1 more source

Seguimento clínico de dois pacientes brasileiros com MODY-glicoquinase (MODY2) e descrição de uma nova mutação [PDF]

, 2012
Mutations in the glucokinase gene (GCK) account for many cases of monogenic diabetes featuring maturity-onset diabetes of the young type 2 (MODY2). The clinical pattern of this form of hyperglycemia is rather stable, with a slight elevation in blood ...
Chacra, Antonio Roberto, Dellamanna, Thais, Dias-da-Silva, Magnus Régios, Furuzawa, Gilberto, Kunii, Ilda S., Maciel, Rui Monteiro de Barros, Reis, André Fernandes, Rolim, Ana Luiza   +7 more
core   +3 more sources

Functional characterization of a novel KCNJ11 in frame mutation-deletion associated with infancy-onset diabetes and a mild form of intermediate DEND: A battle between K(ATP) gain of channel activity and loss of channel expression [PDF]

, 2013
ATP-sensitive potassium (K(ATP)) channels are widely distributed in various tissues and cell types where they couple cell metabolism to cell excitability.
Barbetti, Fabrizio, Battaglia, Domenica, Colombo, Carlo, Crino, Antonino, Grasso, Valerie, Li, Anlong, Lin, Yu-Wen, Nichols, Colin G   +7 more
core   +2 more sources

Functional hyperactivity of hepatic glutamate dehydrogenase as a cause of the hyperinsulinism/hyperammonemia syndrome: effect of treatment [PDF]

, 2000
OBJECTIVE: The combination of persistent hyperammonemia and hypoketotic hypoglycemia in infancy presents a diagnostic challenge. Investigation of the possible causes and regulators of the ammonia and glucose disposal may ...
Duran, M. (Marinus), Huijmans, J.G.M. (Jan), Klerk, J.B.C. (Johannes) de, Rovers, M.J., Scholte, H.R. (Hans)   +4 more
core  

Congenital Hyperinsulinism: Diagnosis and Treatment Update

Journal of Clinical Research in Pediatric Endocrinology, 2018
Pancreatic β-cells are finely tuned to secrete insulin so that plasma glucose levels are maintained within a narrow physiological range (3.5-5.5 mmol/L). Hyperinsulinaemic hypoglycaemia (HH) is the inappropriate secretion of insulin in the presence of low plasma glucose levels and leads to severe and persistent hypoglycaemia in neonates and children ...
Demirbilek, Hüseyin, Hussain, Khalid
openaire   +3 more sources