Brain injury due to persistent hyperinsulinemic hypoglycemia of infancy [PDF]
, 2007 A
De Visschere, Pieter +3 more
core +2 more sources
Familial Focal Congenital Hyperinsulinism [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2011 Background:Congenital hyperinsulinism (CHI) is a cause of persistent hypoglycemia. Histologically, there are two subgroups, diffuse and focal. Focal CHI is a consequence of two independent events, inheritance of a paternal mutation in ABCC8/KCNJ11 and paternal uniparental isodisomy of chromosome 11p15 within the embryonic pancreas, leading to an ...
Sian Ellard +12 more
openaire +2 more sources
Glucocorticoid-Induced Hyperinsulinism in a Preterm Neonate with Inherited ABCC8 Variant
Metabolites, 2022 Glucose homeostasis is a real challenge for extremely preterm infants (EPIs) who have both limited substrate availability and immature glucose metabolism regulation.
Emmanuelle Motte-Signoret +4 more
doaj +1 more source
A link between solar events and congenital malformations: Is ionizing radiation enough to explain it? [PDF]
Journal of Geophysical Research: Space Physics 120.3, 1537-1542
(2015), 2015 Cosmic rays are known to cause biological effects directly and through ionizing radiation produced by their secondaries. These effects have been detected in airline crews and other specific cases where members of the population are exposed to above average secondary fluxes.
arxiv +1 more source
Pancreatic endocrine and exocrine function in children following near-total pancreatectomy for diffuse congenital hyperinsulinism. [PDF]
, 2016 Published onlineJournal ArticleCONTEXT: Congenital hyperinsulinism (CHI), the commonest cause of persistent hypoglycaemia, has two main histological subtypes: diffuse and focal.
Alam, S +6 more
core +1 more source
Evaluation and management of neonatal onset hyperinsulinemic hypoglycemia: a single neonatal center experience [PDF]
, 2023 Objectives: To evaluate the clinical characteristics and treatment options of neonates requiring prolonged hospitalization due to persistent hyperinsulinemic hypoglycemia (HH).
Bezirganoğlu, Handan +4 more
core +1 more source
[Focal congenital hyperinsulinism].
Orvosi Hetilap, 2023 In congenital hyperinsulinemic hypoglycemia - the most common cause of persistent hypoglycemia in infancy - a focal lesion can be identified in 50% of the cases. With appropriate medical care based upon early diagnosis, these patients can be cured by the
Zsuzsa Tallós +8 more
semanticscholar +1 more source
A discrete event system specification (DEVS)-based model of consanguinity [PDF]
Journal of theoretical biology, 285(1), 103-112 (2011), 2017 Consanguinity or inter-cousin marriage is a phenomenon quite prevalent in certain regions around the globe. Consanguineous parents have a higher risk of having offspring with congenital disorders. It is difficult to model large scale consanguineous parental populations because of disparate cultural issues unique to regions and cultures across the globe.
arxiv +1 more source
Congenital hyperinsulinism with hyperammonaemia
Case Reports, 2010 Congenital hyperinsulinism is considered to be the most frequent cause of persistent recurrent hypoglycaemia in infants. The clinical presentation and response to pharmacological treatment may vary significantly depending on the underlying pathology. We report a case of a female infant with mild but early onset of recurrent hypoglycaemia.
Hubert Fahnenstich +2 more
openaire +4 more sources
Glutamate dehydrogenase hyperinsulinism: mechanisms, diagnosis, and treatment
Orphanet Journal of Rare Diseases, 2023 Congenital hyperinsulinism (CHI) is a genetically heterogeneous disease, in which intractable, persistent hypoglycemia is induced by excessive insulin secretion and increased serum insulin concentration.
Qiao Zeng, Yan-Mei Sang
doaj +1 more source