Results 61 to 70 of about 278,652 (177)
A Current Perspective on Delayed Puberty and Its Management
JCRPEDelayed puberty is defined as the lack of development of secondary sex characteristics in childhood. Based on a review of the literature, delayed puberty can be divided into three main categories: (i) hypergonadotropic hypogonadism (congenital and ...
Ayhan Abacı, Özge Besci
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Male hypogonadotropic hypogonadism in various genetic disorders [PDF]
, 2020 Introduction and purpose: Male hypogonadism is diagnosed in patients with total testosterone under 9-12nmol/L (250-350ng/dl) in serum which is associated with numerous symptoms which can severely lower the quality of patients life.
Maciej Dobosz +13 more
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Congenital Hypogonadotropic Hypogonadism and Kallmann Syndrome: Past, Present, and Future [PDF]
Endocrinology and Metabolism, 2015 The proper development and coordination of the hypothalamic-pituitary-gonadal (HPG) axis are essential for normal reproductive competence. The key factor that regulates the function of the HPG axis is gonadotrophin-releasing hormone (GnRH).
Soo-Hyun Kim
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Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source
, 2012 Schematic depicting time of diagnosis, treatment history, and reversal in 6 men with congenital hypogonadotropic hypogonadism.
Eeva-Maria Laitinen (157880) +5 more
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Gnrh in the treatment of hypogonadotropic hypogonadism
, 2021 Gonadotropin-releasing hormone (GnRH) is the focus of the scientific debate for the treatment of hypogonadotropic hypogonadism. Sexual maturation and reproductive function depend on the pulsatile secretion of GnRH that are mainly congenital and may or ...
Rinaldi M. +5 more
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Rare FGFR1 c.1977+1G>A splice-site variant in hypogonadotropic hypogonadism-2 with anosmia
Genetics & ApplicationsCongenital idiopathic hypogonadotropic hypogonadism (IHH) is a rare disorder caused by deficient gonadotropin-releasing hormone secretion or action and may present with anosmia when the olfactory system is affected.
Veysel Sabri Hançer +4 more
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CHARGE Syndrome: What an Otolaryngologist Should Know—A Systematic Review and Meta‐Analysis
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract Objective To synthesize the prevalence of otolaryngologic manifestations in CHARGE syndrome (CS) to support otolaryngologists in delivering comprehensive management. Data Sources PubMed/MEDLINE, Embase, and Google Scholar were searched for English‐ and French‐language studies published from January 1980 through January 2025.
Camille Caron +5 more
wiley +1 more source
Reversible congenital hypogonadotropic hypogonadism in patients with CHD7, FGFR1 or GNRHR mutations. [PDF]
PLoS ONE, 2012 BACKGROUND: Congenital hypogonadotropic hypogonadism (HH) is a rare cause for delayed or absent puberty. These patients may recover from HH spontaneously in adulthood.
Eeva-Maria Laitinen +5 more
doaj +1 more source
Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel +5 more
wiley +1 more source