Results 11 to 20 of about 100,362 (316)

Economic evaluation of pneumococcal conjugate vaccination in The Gambia [PDF]

BMC Infectious Diseases, 2010
Background Gambia is the second GAVI support-eligible country to introduce the 7-valent pneumococcal conjugate vaccine (PCV7), but a country-specific cost-effectiveness analysis of the vaccine is not available.
Kim Sun-Young, Lee Gene, Goldie Sue J
doaj   +5 more sources

Evaluation of Haemophilus influenzae Type B Conjugate Vaccine (Meningococcal Protein Conjugate) in Canadian Infants [PDF]

Canadian Journal of Infectious Diseases, 1994
Objective: To assess adverse effects and immune responses with a three-dose series of Haemophilus influenzae type b meningococcal protein conjugate (PedvaxHIB or Hib.OMP) vaccine, including any immunological response alterations from concurrent ...
David W Scheifele, Gordean L Bjornson, William G Meekison, Roland Guasparini, Leslie A Mitchell   +4 more
doaj   +2 more sources

Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates [PDF]

ACS Medicinal Chemistry Letters, 2019
Antibody-drug conjugates (ADCs) that incorporate the exatecan derivative DXd in their payload are showing promising clinical results in solid tumor indications. The payload has an F-ring that also contains a second chiral center, both of which complicate its synthesis and derivatization.
Wei Li, Karen H. Veale, Qifeng Qiu, Kerstin W. Sinkevicius, Erin K. Maloney, Juliet A. Costoplus, Janet Lau, Helen L. Evans, Yulius Setiady, Olga Ab, Stephen M. Abbott, Jenny Lee, Somsinee Wisitpitthaya, Anna Skaletskaya, Lintao Wang, Thomas A. Keating, Ravi V. J. Chari, Wayne C. Widdison   +17 more
openaire   +2 more sources

Vaccination of risk groups in England using the 13 valent pneumococcal conjugate vaccine: economic analysis. [PDF]

, 2012
OBJECTIVE: To estimate the cost effectiveness of vaccinating people with high risk conditions against invasive pneumococcal disease using the 13 valent pneumococcal conjugate vaccine.
Edmunds, W. John, van Hoek, Albert Jan, Trotter, Caroline L, Rozenbaum, Mark H., C. L. Trotter, Miller, Elizabeth, Rozenbaum, Mark H, D. Fleming, Trotter, Caroline L., E. Miller, M. H. Rozenbaum, Edmunds, W John, W. J. Edmunds, Fleming, Douglas, A. J. van Hoek   +14 more
core   +1 more source

Cost effectiveness of pediatric pneumococcal conjugate vaccines: a comparative assessment of decision-making tools. [PDF]

, 2011
BACKGROUND: Several decision support tools have been developed to aid policymaking regarding the adoption of pneumococcal conjugate vaccine (PCV) into national pediatric immunization programs.
A.M. Henao, Henao, Ana Maria, J. Hombach, Hutubessy, Raymond, Edmunds, John W, Beutels, Philippe, Joachim Hombach, Hutubessy Raymond, R. Somkrua, Chaiyakunapruk, Nathorn, Hombach, Joachim, R. Hutubessy, John W Edmunds, Ana Maria Henao, Philippe Beutels, Hombach Joachim, Nathorn Chaiyakunapruk, Henao Ana Maria, Edmunds John W, P. Beutels, Somkrua, Ratchadaporn, Edmunds, John W., Melegaro, Alessia, N. Chaiyakunapruk, Ratchadaporn Somkrua, Chaiyakunapruk Nathorn, Beutels Philippe, Raymond Hutubessy, Melegaro Alessia, Somkrua Ratchadaporn, Alessia Melegaro, W.J. Edmunds   +31 more
core   +1 more source

Evaluation of the Molecular Recognition of Peptide-Conjugated Polymer

Analytical Sciences, 2003
We have recently reported on dodecamer peptides (HPPMDFHKAMTR, CHPQPLKSRNPL) which recognize 52-58th and 197-203rd amino acid sequences of glucose oxidase (GOx) by screening via a phage random peptide library. In this study, a side-chain protected peptide monomer (PPM) was synthesized using two peptides (HPPMDFHKAMTR, SHPQPLKSRNPL) and acryloyl ...
ITODA, Kazuya, TAMIYA, Eiichi, YOKOYAMA, Kenji   +2 more
openaire   +3 more sources

7-Valent pneumococcal conjugate vaccination in England and Wales: is it still beneficial despite high levels of serotype replacement? [PDF]

, 2011
BACKGROUND: The UK introduced the 7-valent pneumococcal conjugate vaccine (PCV7) into the national vaccination program in September 2006. Previous modelling assumed that the likely impact of PCV7 on invasive pneumococcal disease (IPD) would be similar to
Nigel Gay, Andrews, Nick, George, Robert, Robert George, Gay Nigel, Miller, Elizabeth, George Robert, Pauline A Waight, Miller Elizabeth, Yoon Hong Choi, N. Gay, Choi, Yoon Hong, Pauline A. Waight, Andrews Nick, R. George, Nick Andrews, Waight Pauline A., Jit, Mark, Gay, Nigel, Jit Mark, Y.H. Choi, Choi Yoon Hong, Elizabeth Miller, M. Jit, P.A. Waight, Melegaro, Alessia, E. Miller, Mark Jit, N. Andrews, Waight, Pauline A, Melegaro Alessia, Alessia Melegaro   +31 more
core   +1 more source

Cost-effectiveness of Haemophilus influenzae type b conjugate vaccine in low- and middle-income countries: regional analysis and assessment of major determinants. [PDF]

, 2013
OBJECTIVES: To estimate the cost-effectiveness of Haemophilus influenzae type b (Hib) conjugate vaccine in low- and middle-income countries and identify the model variables, which are most important for the result.
Clark, Andrew, Griffiths, Ulla Kou, Hajjeh, Rana   +2 more
core   +1 more source

Dose-specific efficacy of Haemophilus influenzae type b conjugate vaccines: a systematic review and meta-analysis of controlled clinical trials. [PDF]

, 2012
Global coverage of infant Haemophilus influenzae type b (Hib) vaccination has increased considerably during the past decade, partly due to GAVI Alliance donations of the vaccine to low-income countries. In settings where large numbers of children receive
Clark, A, Mulholland, KE, Griffiths, UK, Miners, A, Gessner, B, Sanderson, C, Sedyaningsih, ER   +6 more
core   +1 more source

Synthesis and evaluation of the functional oligonucleotides-PEG conjugates [PDF]

Nucleic Acids Symposium Series, 2004
We have previously demonstrated that the phenylsulfide and phenylsulfoxide derivatives of 2-amino-6-vinylpurine exhibit efficient cross-linking with high selectivity towards cytidine through synchronous activation within duplex. In this study, we synthesized their conjugates with PEG for possible application to in vitro as well as in vivo antisense ...
Ali Md, Monsur, Fumi, Nagatsugi, Motoi, Oishi, Yukio, Nagasaki, Kazunari, Kataoka, Shigeki, Sasaki   +5 more
openaire   +2 more sources