Results 31 to 40 of about 100,362 (316)

Preparation of a nanovaccine against Brucella melitensis M16 based on PLGA nanoparticles and oligopolysaccharide antigen

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Brucellosis is one of the most common and important diseases between humans and animals. Herein, we developed a nanovaccine against Brucella melitensis based on oligopolysaccharide (OPS) antigen and PLGA nanoparticles.
Masoud Maleki, Mojtaba Salouti, Mehdi Shafiee Ardestani, Alireza Talebzadeh   +3 more
doaj   +1 more source

Vaccine-Preventable Haemophilus influenza Type B Disease Burden and Cost-Effectiveness of Infant Vaccination in Indonesia [PDF]

, 2008
Background: Most of Asia, including Indonesia, does not use Haemophilus influenzae type b (Hib) conjugate vaccines. We estimated total vaccine-preventable disease burden and the cost-effectiveness of Hib conjugate vaccine in Indonesia.
Walker, Damian G, Mulholland, Edward Kim, Sedyaningsih, Endang R, Sutanto, Agustinus, Steinhoff, Mark, Nadjib, Mardiati, Linehan, Mary, Mercer, Dave, Gessner, Bradford D, Griffiths, Ulla K   +9 more
core   +1 more source

Pneumococcal carriage in sub-Saharan Africa--a systematic review. [PDF]

, 2014
BACKGROUND: Pneumococcal epidemiology varies geographically and few data are available from the African continent. We assess pneumococcal carriage from studies conducted in sub-Saharan Africa (sSA) before and after the pneumococcal conjugate vaccine (PCV)
Bottomley, Christian, Andrew Hall, Richard A. Adegbola (20657), Hall, Andrew, Hall Andrew, Effua Usuf (334925), Effua Usuf, Christian Bottomley, Adegbola Richard A., Bottomley Christian, Adegbola, Richard A, Usuf, Effua, Usuf Effua, Andrew Hall (223292), Richard A Adegbola, Christian Bottomley (144483)   +15 more
core   +1 more source

The Synthesis and Preliminary Anticancer Evaluation of 6-Mercaptopurine -Methotrexate Conjugate as Possible Mutual Prodrug

Iraqi Journal of Pharmaceutical Sciences, 2019
Small molecules drug conjugate mutual prodrug design  (SMDC) composed of folate &lethal agent conjugate  , rigidly bonded via hydrophilic bridge& self immolative disulfide  bond   ;  represent new interesting approaches for cancer treatment , the ...
Asmaa Safwan Al-darraji, Mohamed H.Mohamed   +1 more
doaj   +1 more source

Costs of vaccine delivery in the Gambia before and after, pentavalent and pneumococcal conjugate vaccine introductions.

, 2014
BACKGROUND: The Gambia introduced seven-valent pneumococcal conjugate vaccine (PCV) in August 2009 and switched to 13-valent PCV in April 2011. In April 2009 monovalent hepatitis B and combined Diphtheria-Tetanus-Pertussis and Haemophilus influenzae type
Lowe-Jallow, Y, Mackenzie, G, Atherly, D, Griffiths, UK, Boye, B, Usuf, E, Suraratdecha, C   +6 more
core   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Data set on the synthesis and properties of 2′,3′-dideoxyuridine triphosphate conjugated to SiO2 nanoparticles

Data in Brief, 2018
SiO2 nanoparticles were used as a transport system for cellular delivery of phosphorylated 2′,3′-dideoxyuridine to increase its anticancer potency. This data set is related to the research article entitled “2′,3′-Dideoxyuridine triphosphate conjugated to
Svetlana V. Vasilyeva, Inga R. Grin, Boris P. Chelobanov, Dmitry A. Stetsenko   +3 more
doaj   +1 more source

A Novel Curcumin-Mycophenolic Acid Conjugate Inhibited Hyperproliferation of Tumor Necrosis Factor-Alpha-Induced Human Keratinocyte Cells

Pharmaceutics, 2021
Curcumin (CUR) has been used as adjuvant therapy for therapeutic application in the treatment of psoriasis through several mechanisms of action.
Yonelian Yuyun, Pahweenvaj Ratnatilaka Na Bhuket, Wiwat Supasena, Piyapan Suwattananuruk, Kemika Praengam, Opa Vajragupta, Chawanphat Muangnoi, Pornchai Rojsitthisak   +7 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Comment on Gomez et. al. “Response to article by Wasserman et. al. (2018) ‘Modelling the sustained use of the 13-valent pneumococcal conjugate vaccine compared to switching to the 10-valent vaccine in Mexico’”

Human Vaccines & Immunotherapeutics, 2019
In a recent Letter, Gomez et. al. provided a critique of our original analysis estimating the clinical and economic impact of switching from the 13-valent (PCV13) to the 10-valent (PCV10) pneumococcal conjugate vaccine in Mexico.
Matt Wasserman, Maria Gabriela Palacios, Ana Gabriela Grajales, Michele Wilson, Cheryl McDade, Raymond Farkouh   +5 more
doaj   +1 more source