Results 21 to 30 of about 100,362 (316)

Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody–Drug Conjugate Targeting 5T4 [PDF]

Molecular Cancer Therapeutics, 2017
Abstract Antibody–drug conjugates (ADC) are used to selectively deliver cytotoxic agents to tumors and have the potential for increased clinical benefit to cancer patients. 5T4 is an oncofetal antigen overexpressed on the cell surface in many carcinomas on both bulk tumor cells as well as cancer stem cells (CSC), has very limited ...
Jay, Harper, Christopher, Lloyd, Nazzareno, Dimasi, Dorin, Toader, Rose, Marwood, Leeanne, Lewis, David, Bannister, Jelena, Jovanovic, Ryan, Fleming, Francois, D'Hooge, Shenlan, Mao, Allison M, Marrero, Martin, Korade, Patrick, Strout, Linda, Xu, Cui, Chen, Leslie, Wetzel, Shannon, Breen, Lilian, van Vlerken-Ysla, Sanjoo, Jalla, Marlon, Rebelatto, Haihong, Zhong, Elaine M, Hurt, Mary Jane, Hinrichs, Keven, Huang, Philip W, Howard, David A, Tice, Robert E, Hollingsworth, Ronald, Herbst, Adeela, Kamal   +29 more
openaire   +2 more sources

A longitudinal household study of Streptococcus pneumoniae nasopharyngeal carriage in a UK setting. [PDF]

, 2005
A 10-month longitudinal household study of pre-school children and their families was undertaken with monthly visits collecting epidemiological data and nasopharyngeal swabs in Hertfordshire, England from 2001 to 2002.
Martin, SA, Edmunds, WJ, Hussain, M, George, R, Efstratiou, A, Miller, E, Pebody, RG, Melegaro, A, Talukdar, R   +8 more
core   +1 more source

Moving force identification based on modified preconditioned conjugate gradient method [PDF]

, 2018
This paper develops a modified preconditioned conjugate gradient (M-PCG) method for moving force identification (MFI) by improving the conjugate gradient (CG) and preconditioned conjugate gradient (PCG) methods with a modified Gram-Schmidt algorithm. The
Zhen Chen, Chen, Zhen, Nguyen, Andy, Andy Nguyen, Chan, Tommy H. T., Tommy H.T. Chan   +5 more
core   +1 more source

Design, Synthesis, and Evaluation of a Novel Cytotoxic Peptide-Doxorubicin Conjugate Targeting Triple-Negative Breast Cancer

, 2021
The aim of this thesis was to design, synthesize, and characterize a novel peptide-doxorubicin conjugate, evaluate in vitro stability and cytotoxicity properties of the conjugate and study its mechanism for uptake into the triple-negative breast cancer ...
Ziaei, Elmira
core   +1 more source

Preparation and Evaluation of Tumor-Targeting Peptide−Oligonucleotide Conjugates [PDF]

Bioconjugate Chemistry, 2000
Enormous progress has been made in the development of antisense oligodeoxynucleotides (ODNs) as therapeutic agents inhibiting gene expression. Unfortunately, the therapeutical application of ODNs is still held back because of the low cellular uptake and the lack of specific transport into particular cells.
Mier, Walter, Eritja Casadellà, Ramón, Mohammed, Ashour, Haberkorn, Uwe, Eisenhut, Michael   +4 more
openaire   +3 more sources

The role of economic evaluation in vaccine decision making: focus on meningococcal group C conjugate vaccine.

, 2005
In recent years, several countries have experienced increases in the incidence of serogroup C meningococcal disease. It can be controlled with older polysaccharide vaccines and particularly the recently developed conjugate vaccines.
Trotter, CL, Edmunds, WJ, Edmunds, W. John, Postma, Maarten J., Postma, Maarten; id_orcid, Postma, Maarten J, Trotter, Caroline L, Philippe Beutels, Robert Welte, Trotter, Caroline L., Welte, R., Beutels, P.H., Edmunds, W John, Beutels, Philippe, Postma, M, Edmunds, W.J., Postma, Maarten, Caroline L Trotter, Welte, Robert, Welte, R, Beutels, P, W John Edmunds, Maarten J Postma, Trotter, C.L.   +23 more
core   +2 more sources

AUTOMATIC EVALUATION OF THE INITIAL GEOPOSITIONING ACCURACY FOR LARGE AREA PLANETARY REMOTE SENSING IMAGES [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2020
The photogrammetric processing of large area planetary remote sensing images is still a very challenging work. In addition to the lack of ground control data and poor tie points extraction, the insufficient knowledge of the initial geopositioning ...
X. Geng, X. Geng, Q. Xu, J. Wang, S. Xing   +4 more
doaj   +1 more source

Synthesis and Cytotoxicity Evaluation of DOTA-Conjugates of Ursolic Acid [PDF]

Molecules, 2019
In this study, we report the synthesis of several amine-spacered conjugates of ursolic acid (UA) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA). Thus, a total of 11 UA-DOTA conjugates were prepared holding various oligo-methylene diamine spacers as well as different substituents at the acetate units of DOTA including tert-butyl ...
Michael Kahnt, Sophie Hoenke, Lucie Fischer, Ahmed Al-Harrasi, René Csuk   +4 more
openaire   +4 more sources

Cytotoxicity Evaluation of Photosensitizer-Conjugated Hexagonal Upconverting Nanoparticles

Nanomaterials, 2023
In this report, we synthesized hexagonal NaYF4:Yb,Er upconverting nanoparticles (UCNPs) of 171 nm in size with a narrow particle size distribution. To address their colloidal stabi-lity in aqueous media and to incorporate a photosensitizer that can produce reactive singlet oxygen (1O2) to kill tumor cells, UCNPs were conjugated with 6-bromohexanoic ...
Mykhailo Nahorniak, Viktoriia Oleksa, Taras Vasylyshyn, Ognen Pop-Georgievski, Eliška Rydvalová, Marcela Filipová, Daniel Horák   +6 more
openaire   +4 more sources

Dermatan Sulfate: Structure, Biosynthesis, and Biological Roles

Biomolecules
Dermatan sulfate (DS) is a remarkably versatile glycosaminoglycan that plays critical roles across a wide array of biological processes. Its unique structure, characterized by repeating disaccharide units of N-acetyl-D-galactosamine (GalNAc) and Iduronic
Congcong Chen, Xuyang Zhang, Weiting Zhang, Dahai Ding, Ravi Sankar Loka, Kun Zhao, Peixue Ling, Shuaishuai Wang   +7 more
doaj   +1 more source