Results 61 to 70 of about 100,362 (316)
Revista Cubana de Investigaciones Biomédicas, 2007 Se propuso un algoritmo analítico por etapas para la evaluación de conjugados inmunoenzimáticos. Estos deben ser evaluados en el sistema donde van a ser empleados.
Tammy Fernández Romero +3 more
doaj
Iraqi Journal of Pharmaceutical Sciences, 2019 Small molecules drug conjugate mutual prodrug design (SMDC) composed of folate and lethal agent conjugate, rigidly bonded via hydrophilic bridge and self immolative disulfide bond ; represent new interesting approaches for cancer treatment , the ...
Asmaa S. Al-Darraji, Mohamed H.Mohamed
doaj +1 more source
Pharmaceutics, 2021 Chemotherapy is the main treatment for triple-negative breast cancer (TNBC), a subtype of breast cancer that is aggressive with a poor prognosis. While chemotherapeutics are potent, these agents lack specificity and are equally toxic to cancer and ...
Azam Saghaeidehkordi +3 more
doaj +1 more source
Retro-1-Oligonucleotide Conjugates. Synthesis and Biological Evaluation
Molecules, 2019 Addition of small molecule Retro-1 has been described to enhance antisense and splice switching oligonucleotides. With the aim of assessing the effect of covalently linking Retro-1 to the biologically active oligonucleotide, three different derivatives of Retro-1 were prepared that incorporated a phosphoramidite group, a thiol or a 1,3-diene ...
Jordi Agramunt +4 more
openaire +4 more sources
, 2021 The obstetric conjugate represents the shortest anteroposterior diameter of the birth canal and it reflects the capacity of the pelvic inlet to allow the passage and the engagement of the fetal head.
Elvira Di Pasquo +17 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Delivery of mRNA Vaccine against SARS-CoV-2 Using a Polyglucin:Spermidine Conjugate
Vaccines, 2021 One of the key stages in the development of mRNA vaccines is their delivery. Along with liposome, other materials are being developed for mRNA delivery that can ensure both the safety and effectiveness of the vaccine, and also facilitate its storage and ...
Larisa I. Karpenko +15 more
doaj +1 more source
Advances in preclinical evaluation of experimental antibody-drug conjugates
Cancer Drug Resistance, 2021 The ability to chemically modify monoclonal antibodies with the attachment of specific functional groups has opened up an enormous range of possibilities for the targeted treatment and diagnosis of cancer in the clinic. As the number of such antibody-based drug candidates has increased, so too has the need for more stringent and robust preclinical ...
Lyons, Scott K. +2 more
openaire +3 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Microbubble–liposome conjugate [PDF]
Nanobiomedicine, 2016 Liposome–microbubble conjugates are considered as better targeted drug delivery vehicles compared to microbubbles alone. The microbubble in the integrated drug delivery system delivers the drug intracellularly on the target, whereas the liposome component allows loading of high drug dose and extravasation through leaky vasculature. In this work, a new
Malik, Ritu +2 more
openaire +4 more sources