Results 71 to 80 of about 100,362 (316)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A New Conjugate Gradient for Unconstrained Optimization Based on Step Size of Barzilai and Borwein
Science Journal of University of Zakho, 2016 In this paper, a new formula of is suggested for conjugate gradient method of solving unconstrained optimization problems based on step size of Barzilai and Borwein.
Salah G. Shareef, Alaa L. Ibrahim
doaj
The design and synthesis of an antibacterial phenothiazine–siderophore conjugate
Beilstein Journal of Organic Chemistry, 2018 Siderophore–antibiotic conjugates consist of an antibiotic covalently linked by a tether to a siderophore. Such conjugates can demonstrate enhanced uptake and internalisation to the bacterial cell resulting in significantly reduced MIC values and ...
Abed Tarapdar +4 more
doaj +1 more source
A New Conjugate Gradient Coefficient for Unconstrained Optimization Based On Dai-Liao
Science Journal of University of Zakho, 2019 This paper, proposes a new conjugate gradient method for unconstrained optimization based on Dai-Liao (DL) formula; descent condition and sufficient descent condition for our method are provided.
Alaa L. Ibrahim +2 more
doaj +1 more source
Synthesis and evaluation of biological properties of ferrocenyl–podophyllotoxin conjugates
Dalton Transactions, 2017 Ferrocenyl–podophyllotoxin conjugates have been synthesised and their antiproliferative activity, influence on cell cycle, and interactions with tubulin were evaluated.
Anna Wieczorek +4 more
openaire +4 more sources
Economic evaluation of delivering Haemophilus influenzae type b vaccine in routine immunization services in Kenya. [PDF]
, 2007 OBJECTIVE: Haemophilus influenzae type b (Hib) vaccine was introduced into routine immunization services in Kenya in 2001. We aimed to estimate the cost-effectiveness of Hib vaccine delivery. METHODS: A model was developed to follow the Kenyan 2004 birth
Akumu, Angela Oloo +8 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2022 Coronavirus disease 2019 (COVID-19) pandemic, a global health threat, was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 papain-like cysteine protease (PLpro) was recognized as a promising drug target because of ...
Zhang, Yichi +10 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Design and Evaluation of RNA Aptamer–Mediated Delivery of C/EBPβ siRNA for Oncological Therapy
Journal of Nucleic AcidsThe CCAAT/enhancer-binding protein beta (CEBPB or C/EBPβ) is a transcription factor that plays a critical role in cellular differentiation, metabolism, and immune response.
D. Vasconcelos +9 more
doaj +1 more source