Results 61 to 70 of about 115,778 (235)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Conjugate Heat Transfer in Diverging Microchannels [PDF]
, 2015 A numerical study has been carried out to determine the effects of axial wall conduction during single-phase steady laminar flow of fluid through rectangular diverging (across the length of the channel) cross-sectional microchannel involving conjugate ...
Rajesh Kumar, V
core
Heat and mass transfer in air-fed pressurised suits [PDF]
, 2008 Air-fed pressurised suits are used to protect workers against contamination and hazardous environments. The specic application here is the necessity for regular clean-up maintenance within the torus chamber of fusion reactors.
Atherton, MA +4 more
core +5 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Engineering Applications of Computational Fluid MechanicsThe fluid's heat transfer properties must be effectively utilized to create efficient heat exchangers. In various existing studies, the application of forced convection leads to pressure drops in conjugate heat transfer systems due to the nanoparticles ...
Anilkumar SH +4 more
doaj +1 more source
Numerical Simulation of Solar Radiation and Conjugate Heat Transfer through Cabin Seat Textile
AUTEX Research Journal, 2020 The solar radiation and the conjugate heat transfer through the cabin seat fabric were investigated numerically with a focus on a comparative analysis of various fabric solar reflectance or reflectivity (SR) and inlet cooling air velocity.
Zhang Yijie, Jia Juhong
doaj +1 more source
Low-Concentration Solar-Power Systems Based on Organic Rankine Cycles for Distributed-Scale Applications: Overview and Further Developments [PDF]
, 2015 This paper is concerned with the emergence and development of low-to-medium-grade thermal-energy-conversion systems for distributed power generation based on thermo- dynamic vapor-phase heat-engine cycles undergone by organic working uids, namely ...
Markides, CN
core +2 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source