Results 1 to 10 of about 51,559 (213)

Development of MenFive®, an affordable pentavalent meningococcal conjugate vaccine (ACYWX) for Africa and beyond [PDF]

Human Vaccines & Immunotherapeutics
Wide use of the groundbreaking vaccine MenAfriVac® has eliminated serogroup A meningococcal meningitis in the African meningitis belt and paved the way for elimination of all meningococcal disease outbreaks with the development, licensure, and ...
Mark R. Alderson, Katie Regan, Lionel Martellet, Nancy Hosken, Prasad S. Kulkarni, Sambhaji S. Pisal, F. Marc LaForce, Rajeev M. Dhere   +7 more
doaj   +2 more sources

Rotavirus spike protein ΔVP8* as a novel carrier protein for conjugate vaccine platform with demonstrated antigenic potential for use as bivalent vaccine

Scientific Reports, 2021
Conjugate vaccine platform is a promising strategy to overcome the poor immunogenicity of bacterial polysaccharide antigens in infants and children. A carrier protein in conjugate vaccines works not only as an immune stimulator to polysaccharide, but ...
Wook-Jin Park, Yeon-Kyung Yoon, Ji-Sun Park, Ruchirkumar Pansuriya, Yeong-Jae Seok, Ravi Ganapathy   +5 more
doaj   +1 more source

Mutant Native Outer Membrane Vesicles Combined with a Serogroup A Polysaccharide Conjugate Vaccine for Prevention of Meningococcal Epidemics in Africa. [PDF]

PLoS ONE, 2013
The meningococcal serogroup A (MenA) polysaccharide conjugate vaccine used in Sub-Saharan Africa does not prevent disease caused by MenW or MenX strains, which also cause epidemics in the region.
Rolando Pajon, Andrew M Fergus, Dan M Granoff   +2 more
doaj   +1 more source

Safety and immunogenicity of a new glycoengineered vaccine against Acinetobacter baumannii in mice

Microbial Biotechnology, 2022
Summary Acinetobacter baumannii poses a serious threat to human health, mainly because of its widespread distribution and severe drug resistance. However, no licensed vaccines exist for this pathogen. In this study, we created a conjugate vaccine against
Xin Li, Chao Pan, Zhicheng Liu, Peng Sun, Xiaoting Hua, Erling Feng, Yunsong Yu, Jun Wu, Li Zhu, Hengliang Wang   +9 more
doaj   +1 more source

Immunogenicity and Safety of the Higher-Valent Pneumococcal Conjugate Vaccine vs the 13-Valent Pneumococcal Conjugate Vaccine in Older Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials. [PDF]

Open Forum Infect Dis
Ngamprasertchai T, Ruenroengbun N, Kajeekul R.   +2 more
europepmc   +3 more sources

Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques

npj Vaccines, 2023
An effective HIV-1 vaccine remains a critical unmet need for ending the AIDS epidemic. Vaccine trials conducted to date have suggested the need to increase the durability and functionality of vaccine-elicited antibodies to improve efficacy.
Danielle Nettere, Shakthi Unnithan, Nicole Rodgers, Junsuke Nohara, Paul Cray, Madison Berry, Caroline Jones, Lawrence Armand, Shuk Hang Li, Stella J. Berendam, Genevieve G. Fouda, Derek W. Cain, Taylor N. Spence, Joshua A. Granek, Clemontina A. Davenport, Robert J. Edwards, Kevin Wiehe, Koen K. A. Van Rompay, M. Anthony Moody, Sallie R. Permar, Justin Pollara   +20 more
doaj   +1 more source

Vaccines against Meningococcal Diseases

Microorganisms, 2020
Neisseria meningitidis is the main cause of meningitis and sepsis, potentially life-threatening conditions. Thanks to advancements in vaccine development, vaccines are now available for five out of six meningococcal disease-causing serogroups (A, B, C, W,
Mariagrazia Pizza, Rafik Bekkat-Berkani, Rino Rappuoli   +2 more
doaj   +1 more source

Vaccine hesitancy and receipt of mandatory and optional pediatric vaccines in Shanghai, China

Human Vaccines & Immunotherapeutics, 2022
Given increased global concern about vaccine hesitancy, this study estimates coverage of mandatory vs non-mandatory vaccines in children, and assesses whether vaccine hesitancy among young parents relates to their childʻs eventual vaccination status in ...
Mengdi Ji, Zhuoying Huang, Jia Ren, Abram L. Wagner   +3 more
doaj   +1 more source

RNA gene profile variation in peripheral blood mononuclear cells from rhesus macaques immunized with Hib conjugate vaccine, Hib capsular polysaccharide and TT carrier protein

BMC Immunology, 2018
Background The Haemophilus influenzae type b (Hib) conjugate vaccine has been widely used in children to prevent invasive Hib disease because of its strong immunogenicity and antibody response induction relative to the capsular polysaccharide (CPS ...
Jing Tang, Ying Zhang, Xiaolong Zhang, Yun Liao, Yongrong Wang, Shengjie Ouyang, Yanchun Che, Miao Xu, Jing Pu, Qi Shen, Zhanlong He, Qiang Ye, Qihan Li   +12 more
doaj   +1 more source

Long Term Impact of Conjugate Vaccines on Haemophilus influenzae Meningitis: Narrative Review

Microorganisms, 2021
H. influenzae serotype b (Hib) used to be the commonest cause of bacterial meningitis in young children. The widespread use of Hib conjugate vaccine has profoundly altered the epidemiology of H. influenzae meningitis.
Mary Paulina Elizabeth Slack
doaj   +1 more source