Results 11 to 20 of about 62,343 (221)
Scientific Reports, 2021 Conjugate vaccine platform is a promising strategy to overcome the poor immunogenicity of bacterial polysaccharide antigens in infants and children. A carrier protein in conjugate vaccines works not only as an immune stimulator to polysaccharide, but ...
Wook-Jin Park +5 more
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Safety and immunogenicity of a new glycoengineered vaccine against Acinetobacter baumannii in mice
Microbial Biotechnology, 2022 Summary Acinetobacter baumannii poses a serious threat to human health, mainly because of its widespread distribution and severe drug resistance. However, no licensed vaccines exist for this pathogen. In this study, we created a conjugate vaccine against
Xin Li +9 more
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Mutant Native Outer Membrane Vesicles Combined with a Serogroup A Polysaccharide Conjugate Vaccine for Prevention of Meningococcal Epidemics in Africa. [PDF]
PLoS ONE, 2013 The meningococcal serogroup A (MenA) polysaccharide conjugate vaccine used in Sub-Saharan Africa does not prevent disease caused by MenW or MenX strains, which also cause epidemics in the region.
Rolando Pajon +2 more
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Vaccine hesitancy and receipt of mandatory and optional pediatric vaccines in Shanghai, China
Human Vaccines & Immunotherapeutics, 2022 Given increased global concern about vaccine hesitancy, this study estimates coverage of mandatory vs non-mandatory vaccines in children, and assesses whether vaccine hesitancy among young parents relates to their childʻs eventual vaccination status in ...
Mengdi Ji +3 more
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On the mechanisms of conjugate vaccines [PDF]
Proceedings of the National Academy of Sciences, 2018 During the last three decades, the development and commercialization of conjugate vaccines against Haemophilus influenzae type b (Hib), pneumococcus, and serogroups C, A, W, and Y of meningococcus contributed to the virtual elimination of bacterial meningitis caused by the bacteria included in the vaccines and to the prevention of diseases that used to
Rino Rappuoli +2 more
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npj Vaccines, 2023 An effective HIV-1 vaccine remains a critical unmet need for ending the AIDS epidemic. Vaccine trials conducted to date have suggested the need to increase the durability and functionality of vaccine-elicited antibodies to improve efficacy.
Danielle Nettere +20 more
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Vaccines against Meningococcal Diseases
Microorganisms, 2020 Neisseria meningitidis is the main cause of meningitis and sepsis, potentially life-threatening conditions. Thanks to advancements in vaccine development, vaccines are now available for five out of six meningococcal disease-causing serogroups (A, B, C, W,
Mariagrazia Pizza +2 more
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Carbohydrate Conjugates in Vaccine Developments [PDF]
Frontiers in Chemistry, 2020 Vaccines are powerful tools that can activate the immune system for protection against various diseases. As carbohydrates can play important roles in immune recognition, they have been widely applied in vaccine development. Carbohydrate antigens have been investigated in vaccines against various pathogenic microbes and cancer.
Shuyao Lang +4 more
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BMC Immunology, 2018 Background The Haemophilus influenzae type b (Hib) conjugate vaccine has been widely used in children to prevent invasive Hib disease because of its strong immunogenicity and antibody response induction relative to the capsular polysaccharide (CPS ...
Jing Tang +12 more
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