Results 261 to 270 of about 1,081,297 (374)

Personalized Neoantigen Vaccine plus Regorafenib Increases Rgs2⁺CD8⁺ T Cells Infiltration and Reprograms the Tumor Microenvironment in Microsatellite Stable Colorectal Cancer Liver Metastases

Advanced Science, EarlyView.
This study synthesized a personalized neoantigen vaccine (Neo‐CRCVAS) and combined it with regorafenib, termed RegoNeo. This combination therapy significantly enhanced antitumor efficacy and promoted long‐term tumor‐specific immune memory in microsatellite stable colorectal cancer liver metastasis (MSS‐CRLM) models by increasing neoantigen‐specific ...
Hengkai Chen, Bin Chen, Yuanfeng Yang, Shoufeng Li, Huajun Cai, Zhicheng Zhuang, Yong Wu, Yuan Gao, Yupeng Chen, Xing Liu, Guoxian Guan, Jinfu Zhuang   +11 more
wiley   +1 more source

Cost effectiveness of a 21-valent pneumococcal conjugate vaccine in adults: A systematic review of economic evaluations. [PDF]

Can Commun Dis Rep
Simmons AE, Ximenes R, Gebretekle GB, Salvadori MI, Wong E, Tuite AR.   +5 more
europepmc   +1 more source

Use of Capsular Polysaccharide–Tetanus Toxoid Conjugate Vaccine for Type II Group BStreptococcusin Healthy Women

, 2000
Carol J. Baker, Lawrence C. Paoletti, Marcia A. Rench, Hilde‐Kari Guttormsen, Vincent J. Carey, Melissa E. Hickman, Dennis L. Kasper   +6 more
openalex   +1 more source

Hyperspectral Imaging Techniques for Lyophilization: Advances in Data‐Driven Modeling Strategies and Applications

Advanced Science, EarlyView.
Lyophilization is a key process used in the production of biotherapeutic products. This article reviews and discusses the application of HSI on lyophilization, and the strategies that use the resulting data to build models. It is intended to provide guidance and insights for non‐specialist researchers and engineers into leveraging HSI and the data ...
Huiwen Yu, Prakitr Srisuma, Cedric Devos, Jie Wang, Allan S. Myerson, Richard D. Braatz   +5 more
wiley   +1 more source

Immunogenicity and reactogenicity of a booster dose of a typhoid conjugate vaccine (TCV) in Malawian pre-school children. [PDF]

EClinicalMedicine
Nampota-Nkomba N, Nyirenda OM, Datta S, Mapemba V, Patel PD, Misiri T, Mwakiseghile F, Ndaferankhande JM, Lipenga B, Oshinsky J, Pasetti MF, Jamka LP, Gordon MA, Laurens MB, Neuzil KM, TyVAC team.   +15 more
europepmc   +1 more source

The Efficacy of aSalmonella typhiVi Conjugate Vaccine in Two-to-Five-Year-Old Children [PDF]

, 2001
Feng Lin, Vô Anh Hó, Ha Ba Khiem, Dang Duc Trach, Phan Van Be Bay, Tran Cong Thanh, Zuzana Kossaczká, Dolores A. Bryla, Joseph Shiloach, John B. Robbins, Rachel Schneerson, Shousun C. Szu, Mai Ngoc Lanh, Steven Hunt, Loc Trinh, Jeanne B. Kaufman   +15 more
openalex   +1 more source

Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities

Advanced Science, EarlyView.
Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil, Josh J. Friesen, Nuthan V. Bathula, Anneke Strumpel, Chia Hao Ho, Ilana Guez, Kristen Y. S. Kong, Andrew J. Varley, Shigeki J. Miyake‐Stoner, Parinaz Aliahmad, Nathaniel S. Wang, Andrew J. Geall, Anna K. Blakney   +12 more
wiley   +1 more source

Development of invasive non-typhoidal Salmonella conjugate vaccines and their evaluation in a trivalent formulation with typhoid conjugate vaccine. [PDF]

Vaccine
An SJ, Yang JS, Chae MH, Woo JS, Kang YE, Ganapathy R, Pansuriya RK, Choi JA, Yoon YK, Lee E, Lee SB, Pandey G, Lee JW, Lee JS, Bae SH, Kweon SW, Kim SJ, Seon SH, Kim JH, Song M.   +19 more
europepmc   +1 more source

Keyhole limpet hemocyanin conjugate vaccines against cancer: The Memorial Sloan Kettering experience [PDF]

, 2001
Cristina Musselli, Philip O. Livingston, Govindaswami Ragupathi   +2 more
openalex   +1 more source

Novel Swelling‐Lytic Cell Death Triggered by Cargo‐Free Ionizable Lipid Nanoparticles

Advanced Science, EarlyView.
A cargo‐free ionizable lipid nanoparticles (ipLNP) is found to induce broad swelling‐lytic cell death across multiple cell types. Cell death may be associated with lysosome membrane destabilization, involving ROS increase, lipid peroxidation, and GSDME cleavage.
Junjun Wu, Zhennan Zhao, Hongsheng Wu, Sihuang Lin, Lin Huang, Guanjie Chen, Yi Yang, Hong Wang, Huijie Yan, Yonghui Shi, Liuyu Zhu, Guosheng Hu, Liling Zheng, Songying Ouyang   +13 more
wiley   +1 more source