Results 31 to 40 of about 1,081,297 (374)

A Vaccine Against Group B Streptococcus: Recent Advances [PDF]

, 2020
Group B streptococcus (GBS) causes a high burden of neonatal and infant disease globally. Implementing a vaccine for pregnant women is a promising strategy to prevent neonatal and infant GBS disease and has been identified as a priority by the World ...
Carreras-Abad, C, Heath, PT, Le Doare, K, Ramkhelawon, L   +3 more
core   +2 more sources

Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults.

New England Journal of Medicine, 2015
BACKGROUND Pneumococcal polysaccharide conjugate vaccines prevent pneumococcal disease in infants, but their efficacy against pneumococcal community-acquired pneumonia in adults 65 years of age or older is unknown. METHODS In a randomized, double-blind,
M. Bonten, S. Huijts, M. Bolkenbaas, Chris Webber, S. Patterson, S. Gault, C. H. van Werkhoven, A. V. van Deursen, E. Sanders, T. Verheij, Michael Patton, A. McDonough, A. Moradoghli-Haftvani, Helen M Smith, Tracey Mellelieu, M. Pride, Graham R. Crowther, B. Schmoele-Thoma, D. Scott, K. Jansen, R. Lobatto, B. Oosterman, Nils Visser, E. Caspers, Andre J. Smorenburg, E. Emini, W. Gruber, D. Grobbee   +27 more
semanticscholar   +1 more source

Is a single dose of meningococcal serogroup C conjugate vaccine sufficient for protection? experience from the Netherlands

BMC Infectious Diseases, 2012
Background The first meningococcal serogroup C (MenC) conjugate vaccine was licensed in 1999 and introduced in the United Kingdom. Countries that have implemented the MenC vaccine since then in their national immunisation programmes use different ...
Kaaijk Patricia, van der Ende Arie, Berbers Guy, van den Dobbelsteen Germie PJM, Rots Nynke Y   +4 more
doaj   +1 more source

Efficacy of Typhoid Conjugate Vaccine in Nepal: An Interim Analysis of a Participant-and Observer-Blinded Randomized Phase III Trial

New England Journal of Medicine, 2019
Background Salmonella Typhi is a major cause of fever in children in low- and middle-income countries. The recently WHO prequalified typhoid conjugate vaccine (TCV) was shown to be efficacious in a human challenge model but no efficacy trials in endemic ...
M. Shakya, Rachel Colin-Jones, K. Theiss-Nyland, M. Voysey, D. Pant, Nicola Smith, Xinxue Liu, S. Tonks, O. Mazur, Yama G Farooq, J. Clarke, J. Hill, A. Adhikari, S. Dongol, A. Karkey, B. Bajracharya, Sarah Kelly, M. Gurung, S. Baker, K. Neuzil, S. Shrestha, B. Basnyat, A. Pollard   +22 more
semanticscholar   +1 more source

Pneumococcal carriage, serotype distribution and risk factors in children with community-acquired pneumonia, 5 years after introduction of the 10-valent pneumococcal conjugate vaccine in Ethiopia [PDF]

, 2019
Background: There is a scarcity of data on pneumococcal serotypes carried by children in Ethiopia. We studied pneumococcal nasopharyngeal carriage rate, serotypes, and risk factors among children with community acquired pneumonia (CAP).
Abebe, Workeabeba, Aseffa, Abraham, Asrat, Daniel, Gebre, Meseret, Hailemariam, Tewodros, Negash, Abel Abera, Vaneechoutte, Mario, Verhaegen, Jan   +7 more
core   +1 more source

Safety and immunogenicity of 15-valent pneumococcal conjugate vaccine (PCV-15) compared to PCV-13 in healthy older adults

Human Vaccines & Immunotherapeutics, 2019
Background: Pneumococcal disease remains a public health priority in adults. Safety and immunogenicity of 2 different formulations of 15-valent pneumococcal conjugate vaccine (PCV15) containing 13 serotypes included in 13-valent pneumococcal conjugate ...
Helen L Stacey, Jeffrey Rosen, James T Peterson, A. Williams-Diaz, Vanita Gakhar, T. Sterling, C. Acosta, Katrina M. Nolan, Jianing Li, Alison Pedley, Patrice Benner, Chitrananda Abeygunawardana, Michael Kosinski, William J. Smith, H. Pujar, L. Musey   +15 more
semanticscholar   +1 more source

Effectiveness of 13-Valent Pneumococcal Conjugate Vaccine Against Hospitalization for Community-Acquired Pneumonia in Older US Adults: A Test-Negative Design

Clinical Infectious Diseases, 2018
Our study demonstrated real-world, direct effectiveness of 13-valent pneumococcal conjugate vaccine against vaccine-type community-acquired pneumonia following introduction into a routine immunization program among adults aged ≥65 years, many of whom had
J. McLaughlin, Q. Jiang, R. Isturiz, H. Sings, D. Swerdlow, B. Gessner, R. Carrico, P. Peyrani, T. Wiemken, William A. Mattingly, J. Ramirez, L. Jodar   +11 more
semanticscholar   +1 more source

Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system. [PDF]

, 2012
Routine use of pneumococcal conjugate vaccines (PCVs) in developing countries is expected to lead to a significant reduction in childhood deaths. However, PCVs have been associated with replacement disease with non-vaccine serotypes.
Adegbola, Richard A, Akinsola, Bolanle, Baldeh, Ignatius, Greenwood, Brian M, Hill, Philip C, Howie, Stephen RC, Ikumapayi, Usman N, Jasseh, Momodou, Knoll, Maria Deloria, Lee, Ellen, Levine, Orin S, Mackenzie, Grant A, Plumb, Ian D, Saha, Debasish, Sambou, Sana, Touray, Kebba, Uchendu, Uchendu, Usuf, Effua, Wattiaux, Andre   +18 more
core   +2 more sources

Pneumococcal carriage in children and their household contacts six years after introduction of the 13-valent pneumococcal conjugate vaccine in England

PLoS ONE, 2018
Background In April 2010, 13-valent pneumococcal conjugate vaccine (PCV13) replaced PCV7 in the infant immunisation schedule in England and Wales. Despite limited serotype replacement in invasive pneumococcal disease (IPD) during the first four post ...
J. Southern, N. Andrews, P. Sandu, C. Sheppard, P. Waight, N. Fry, A. V. van Hoek, E. Miller   +7 more
semanticscholar   +1 more source

Recommendation for use of the newly introduced pneumococcal protein conjugate vaccines in Korea [PDF]

Korean Journal of Pediatrics, 2011
Streptococcus pneumoniae remains a leading cause of invasive infections including bacteremia and meningitis, as well as mucosal infections such as otitis media and pneumonia among children and adults.
Eun Hwa Choi, Kyung Hyo Kim, Yae Jean Kim, Jong Hyun Kim, Su Eun Park, Hoan Jong Lee, Byung Wook Eun, Dae Sun Jo, Kyong Min Choi, Young Jin Hong   +9 more
doaj   +1 more source