Results 81 to 90 of about 51,658 (311)

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Nueva generación de Vacunas Conjugadas Antimeningococica: Fundamentos y Posibilidades a escala Mundial

VacciMonitor, 2009
The serogroup distribution of Neisseria meningitidis strains implicated in invasive disease varies geographically and temporally. Monovalent serogroup C conjugate vaccines have successfully reduced serogroup C disease in countries where they are used ...
Jacqueline Miller, Jan Poolman, Dominique Boutriau   +2 more
doaj  

A Three Component Synthetic Vaccine Containing a β-Mannan T-Cell Peptide Epitope and a β-Glucan Dendritic Cell Ligand

Molecules, 2018
Glycoconjugates prepared from the capsular polysaccharide of several pathogenic bacteria and carrier proteins, such as CRM 197 or tetanus toxoid, have been one of the most successful public health measures to be implemented in the last quarter century. A
David R. Bundle, Eugenia Paszkiewicz, Hassan R. H. Elsaidi, Satadru Sekhar Mandal, Susmita Sarkar   +4 more
doaj   +1 more source

Remote‐Controllable Immune‐Priming Spot Formation Via Nanocomplexed Hydrogel‐Assisted Histotripsy: Immunoasis

Advanced Materials, EarlyView.
A novel immunotherapeutic strategy combines injectable, adjuvant‐loaded hydrogels with externally controlled histotripsy to create immune‐priming sites within tumors. This approach generates millimeter‐sized immune‐activated lesions with flexible, patient‐tailored treatment scheduling, enabling precise immune activation through tumor ablation‐mediated ...
Sung Hoon Kim, Wonseok Choi, Yurim Kim, Hyeongmin Kim, Gu Won Jeong, Hyewon Park, Inchan Youn, Yoon Park, Sungmin Han, Young‐Min Kim   +9 more
wiley   +1 more source

Efficacy of Alum-Adjuvanted Peptide and Carbohydrate Conjugate Vaccine Candidates against Group A Streptococcus Pharyngeal Infection in a Non-Human Primate Model

Vaccines
Vaccine development against group A Streptococcus (GAS) has gained traction in the last decade, fuelled by recognition of the significant worldwide burden of the disease.
Tania Rivera-Hernandez, Diane G. Carnathan, Johanna Richter, Patrick Marchant, Amanda J. Cork, Gayathiri Elangovan, Anna Henningham, Jason N. Cole, Biswa Choudhury, Peter M. Moyle, Istvan Toth, Michael R. Batzloff, Michael F. Good, Paresh Agarwal, Neeraj Kapoor, Victor Nizet, Guido Silvestri, Mark J. Walker   +17 more
doaj   +1 more source

Pneumococcal conjugate vaccination schedules in infants—acquisition, immunogenicity, and pneumococcal conjugate and yellow fever vaccine co-administration study [PDF]

, 2022
Grant A. Mackenzie, Isaac Osei, Rasheed Salaudeen, Ousman Secka, Umberto D’Alessandro, Ed Clarke, Jonas Schmidt-Chanasit, Paul V. Licciardi, Cattram Nguyen, Brian Greenwood, Kim Mulholland   +10 more
openalex   +1 more source

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

One-month evaluation of safety and immunogenicity of a Vi-DT typhoid conjugate vaccine (Bio-TCV®) in Indonesian subjects 6 months to 45 years: A phase III randomized clinical trial

Vaccine: X
Background: Typhoid fever typically affects children and young adults and is a considerable cause of morbidity and mortality. Vaccination is the most effective preventive strategy to control typhoid fever in the short to medium term.
Bernie Endyarni Medise, I. Gusti Ayu Trisna Windiani, Dominicus Husada, Rini Sekartini, Hartono Gunardi, Angga Wirahmadi, Dwiyanti Puspitasari, Leny Kartina, I. Gusti Agung Ngurah Sugitha Adnyana, I. Gusti Lanang Sidiartha, I. Made Dwi Lingga Utama, I. Ketut Agus Somia, Iris Rengganis, Sukamto Koesnoe, Hindra Irawan Satari, Soedjatmiko Soedjatmiko, Sri Rezeki Hadinegoro, Ismoedijanto Ismoedijanto, Parwati Setiono Basuki, Gatot Soegiarto, Soetjiningsih Soetjiningsih, Rini Mulia Sari, Mita Puspita, Aria Kekalih, Sreshta Mukhi, Vianca Samara Andhary, Novilia Sjafri Bachtiar, Sushant Sahastrabuddhe   +27 more
doaj   +1 more source

Is a single infant priming dose of meningococcal serogroup C conjugate vaccine in the United Kingdom sufficient? [PDF]

, 2015
Helen Findlow, Ray Borrow
openalex   +1 more source

The Cost-Effectiveness of 13-Valent Pneumococcal Conjugate Vaccine in Seven Chinese Cities [PDF]

, 2021
Yan Li, Huaqing Wang, Wesley Furnback, Bruce C. M. Wang, Shuiqing Zhu, Peng Dong   +5 more
openalex   +1 more source