Results 81 to 90 of about 17,854 (235)

Metabolic feature profiling and metabolic vulnerability in acute lymphoblastic leukemia

Interdisciplinary Medicine, EarlyView.
For the first time, our study develops a novel metabolic classification and subtyping program, metabolic reprogramming‐based classifier for acute lymphoblastic leukemia, using internal PDT‐ALL‐2016 and external cohorts, which dissects metabolic profiling, clinical outcome, and therapeutic vulnerability for precision metabolic intervention in ALL ...
Xiaojie Liang, Zihong Cai, Bingqing Tang, Zicong Huang, Baiwei Luo, Bingyu Lin, Yunong Yang, Zhihao Jin, Xiaoqing Li, Xiuli Xu, Yeling Deng, Chaoran Lin, Liang Wang, Hongsheng Zhou   +13 more
wiley   +1 more source

Kinetics for the Autoxidation of Conjugated Linoleic Acid

Bioscience, Biotechnology, and Biochemistry, 1999
The oxidation rates for conjugated linoleic acid (CLA), linoleic acid (LA), and their methyl and ethyl esters were measured in aqueous and solvent systems by the induction period method. In an aqueous system, the initiation rate was almost the same for all the samples, except for ethyl conjugated linoleate (ECL).
SEO, Hwan-Sook, ENDO, Yasushi, FUJIMOTO, Kenshiro   +2 more
openaire   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

Interdisciplinary Medicine, EarlyView.
This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao, Xiaowei Chang, Jun Zhang, Yinshan Hong, Wenhui Cao, Zhewu Zhao, Yu‐E. Wang, Yanling Yang   +7 more
wiley   +1 more source

A Green Amphoteric Surfactant Derived From Rapeseed Oil for Enhanced Oil Recovery From Carbonate Acidic Oil Reservoirs

Journal of Surfactants and Detergents, EarlyView.
The Green Amphoteric Surfactant Derived From Rapeseed Oil for Enhanced Oil Recovery From Carbonate Acidic Oil Reservoirs. ABSTRACT Surfactants with both positive and negative functional groups (amphoteric or zwitterionic) are particularly advantageous in acidic oil reservoirs because they remain stable under harsh chemical conditions, tolerate acidic ...
Iman Nowrouzi, Amir H. Mohammadi, Abbas Khaksar Manshad   +2 more
wiley   +1 more source

Biological activities and bioactive constituents of Flammulina velutipes: An updated systematic review

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti‐inflammatory, antitumor, immunomodulatory, and gut microbiota‐regulating effects.
Rıdvan Özgen, Didem Şöhretoğlu, Ayşe Kuruüzüm‐Uz   +2 more
wiley   +1 more source

Macronutrient and micronutrient profiles of meat types: insights into human health and diet

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Despite considerable advances in global health and nutrition, emerging challenges such as population growth, climate change, and limited natural resources continue to threaten food security. Meat remains an essential component of the human diet, supplying high‐quality proteins, essential amino acids, lipids, vitamins, and minerals necessary ...
Özgül Anitaş, Serap Göncü, Fatma Hepsağ, Nazan Koluman, Yesim Ozogul   +4 more
wiley   +1 more source

Bio‐guided fractionation of (9Z)‐5,8,11‐trihydroxyoctadec‐9‐enoic acid from Abelmoschus sagittifolius root as a potent α‐glucosidase inhibitor: An integrated in vitro and in silico study

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Abelmoschus sagittifolius stands out as a valuable medicinal source for developing functional food targeting type 2 diabetes. This study investigated the α‐glucosidase inhibitory potential of an active fraction obtained from A. sagittifolius roots (ASR), enriched in (9Z)‐5,8,11‐trihydroxyoctadec‐9‐enoic acid (OA), using both enzyme ...
Nguyen Phuong Mai, Nguyen Van Quan, Nguyen Dang Duc, Tran Dang Xuan   +3 more
wiley   +1 more source

Conjugated linoleic acid (CLA) isomers in heat-treated vegetable oils

Oléagineux, Corps gras, Lipides, 2001
The aim of this study was to quantify the conjugated linoleic acids (CLA) isomers present in frying oils and to elucidate their structures. For this purpose, used frying oils were collected in restaurants by the Laboratoire Interrégional de la Répression
Juaneda Pierre, Cordier Olivier, Gregoire Stéphane, Sebedio Jean-Louis   +3 more
doaj   +1 more source

Evaluation of agronomic traits and storage stability in novel rice cultivar ‘Baromi3’ combining floury endosperm and lipoxygenase 3 deficiency

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Rice milling characteristics and storage stability are critical traits influencing industrial applications. Floury endosperm rice carrying the flo4‐4 allele is valuable for dry milling but exhibits reduced storage stability associated with altered starch structural characteristics.
Su‐Kyung Ha, Ye‐Ji Lee, Gileung Lee, Hyun‐Sook Lee, Kyeongmin Kang, Jae‐Ryoung Park, Seung Young Lee, Ji‐Eun Kwak, Mina Jin, Ji‐Ung Jeung, Chang Joo Lee, Jung‐Pil Suh   +11 more
wiley   +1 more source