Results 51 to 60 of about 1,279,521 (342)

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Polyamidoamine dendrimer-conjugated triamcinolone acetonide attenuates nerve injury-induced spinal cord microglia activation and mechanical allodynia

Molecular Pain, 2017
Background Accumulating evidence on the causal role of spinal cord microglia activation in the development of neuropathic pain after peripheral nerve injury suggests that microglial activation inhibitors might be useful analgesics for neuropathic pain ...
Hwisung Kim, Boomin Choi, Hyoungsub Lim, Hyunjung Min, Jae Hoon Oh, Sunghyun Choi, Joung Goo Cho, Jong-Sang Park, Sung Joong Lee   +8 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Hydroxyl Group as the ‘Bridge’ to Enhance the Single-Molecule Conductance by Hyperconjugation

Molecules
For designing single-molecule devices that have both conjugation systems and structural flexibility, a hyperconjugated molecule with a σ–π bond interaction is considered an ideal candidate. In the investigation of conductance at the single-molecule level,
Xin Lv, Chang Li, Meng-Meng Guo, Wenjing Hong, Li-Chuan Chen, Qian-Chong Zhang, Zhong-Ning Chen   +6 more
doaj   +1 more source

Heptazine-Based π-Conjugated Materials for Light-Emitting

Frontiers in Chemistry, 2021
On the basis of planar and relatively rigid nitrogen-rich heterocyclic system of the heptazine core, heptazine-based π-conjugated materials have aroused widespread attention over the past decade by virtue of the fascinating electronic, optical, thermal ...
Jie Li, Li Tao, Yanqing Wang, Yali Yao, Qiang Guo   +4 more
doaj   +1 more source

Raman spectroscopy as a versatile tool to study organic biradicals [PDF]

, 2019
Since -conjugated organic molecules were probed as potential semiconducting materials, suitable for replacing the widely used silicon technologies, their structural, optical and conductive properties have been under study to improve their application in ...
Casado-Cordon, Juan, Casanova, David, Medina Rivero, Samara, Zafra, Jose Luis, Zhu, Xiaozhang   +4 more
core  

Imaging through turbid layers by scanning the phase conjugated second harmonic radiation from a nanoparticle [PDF]

, 2010
We demonstrate imaging through a turbid layer by using digital phase conjugation of the second harmonic field radiated from a beacon nanoparticle. We show that the phase-conjugated focus can be displaced from its initial position by illuminating the same
Grange, Rachel, Hsieh, Chia-Lung, Laporte, Grégoire, Psaltis, Demetri, Pu, Ye   +4 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

EGF Functionalized Polymer-Coated Gold Nanoparticles Promote EGF Photostability and EGFR Internalization for Photothermal Therapy. [PDF]

PLoS ONE, 2016
The application of functionalized nanocarriers on photothermal therapy for cancer ablation has wide interest. The success of this application depends on the therapeutic efficiency and biocompatibility of the system, but also on the stability and ...
Catarina Oliveira Silva, Steffen B Petersen, Catarina Pinto Reis, Patrícia Rijo, Jesús Molpeceres, Ana Sofia Fernandes, Odete Gonçalves, Andreia C Gomes, Isabel Correia, Henrik Vorum, Maria Teresa Neves-Petersen   +10 more
doaj   +1 more source

Fluorescent-Antibody Targeting of Insulin-Like Growth Factor-1 Receptor Visualizes Metastatic Human Colon Cancer in Orthotopic Mouse Models. [PDF]

, 2016
Fluorescent-antibody targeting of metastatic cancer has been demonstrated by our laboratory to enable tumor visualization and effective fluorescence-guided surgery.
Bouvet, Michael, Hoffman, Robert M, Lee, Jin Young, Murakami, Takashi, Park, Jeong Youp, Zhang, Yong   +5 more
core   +2 more sources