Results 61 to 70 of about 1,279,521 (342)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Study of immunogenic properties of transmissible gastroenteritis virus antigen conjugated to gold nanoparticles

Journal of Biomedical Photonics & Engineering, 2016
There was performed the study of immunogenic properties of the transmissible gastroenteritis virus antigen conjugated to gold nanoparticles. In comparative immunobiological studies there was found that immunization of guinea pigs driven by the colloidal ...
Pavel V. Mezhenny, Sergej A. Staroverov, Aleksandr S. Fomin, Aleksej A. Volkov, Ivan Y. Domnitsky, Sergey V. Kozlov, Vladislav N. Laskavy, Lev A. Dykman   +7 more
doaj   +1 more source

Symmetry Induced 4-Wave Capillary Wave Turbulence

, 2009
We report theoretical and experimental results on 4-wave capillary wave turbulence. A system consisting of two inmiscible and incompressible fluids of the same density can be written in a Hamiltonian way for the conjugated pair $(\eta,\Psi)$.
Claudio Falcón, Gustavo Düring, I. V. Ryzhenkova, V. E. Zakharov, V. E. Zakharov, V. E. Zakharov, V. E. Zakharov, V. S. L’vov   +7 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Second-generation aptamer-conjugated PSMA-targeted delivery system for prostate cancer therapy

International Journal of Nanomedicine, 2011
Xin Wu1,*, Baoyue Ding1,2,*, Jing Gao3,*, Huanyun Wang4, Wei Fan1, Xiang Wang1,5, Wei Zhang1, Xiaoyu Wang1, Lihua Ye1, Min Zhang1, Xueying Ding3, Jiyong Liu1, Quangang Zhu1, Shen Gao11Department of Pharmaceutics, Changhai Hospital, Second Military ...
Zhu Q, Liu J, Ding X, Zhang M, Ye L, Wang X, Zhang W, Wang X, Fan W, Wang H, Gao J, Ding B, Wu X, Gao S   +13 more
doaj  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Thermodynamic forces, flows, and Onsager coefficients in complex networks

, 2007
We present Onsager formalism applied to random networks with arbitrary degree distribution. Using the well-known methods of non-equilibrium thermodynamics we identify thermodynamic forces and their conjugated flows induced in networks as a result of ...
Agata Fronczak, D. Kondepundi, Janusz A. Hołyst, M. E. J. Newman, Piotr Fronczak, S. Bornholdt, S. N. Dorogovtsev, S. R. Groot   +7 more
core   +1 more source

A Property of Conjugated Systems [PDF]

Nature, 1941
IN a compound of the type X.(CH = CH)nY, the conjugated system is an electronic conductor between the covalent groups X and Y, and there must therefore be a correspondence between such chemical properties of the compound as leave the conjugated system intact and those of the covalent compound X. Y.
openaire   +1 more source