Results 161 to 170 of about 337,623 (298)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Host genetics regulate bacterial plasmid conjugation differentially in avian ceca explant co-culture through secretory miRNA. [PDF]

NPJ Antimicrob Resist
Skow C, Ott LC, Lamont SJ, Mellata M.
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Fluorescence-Based Soil Survival Analysis of the Xenobiotic- and Metal-Detoxifying <i>Streptomyces</i> sp. MC1. [PDF]

Int J Mol Sci
Aparicio JD, Gonzalez Holc VG, Pappalardo CG, Lautru S, Pernodet JL, Polti MA.   +5 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Aptamer-liposome targeted nanotherapeutics for cancer therapy: Bibliometric analysis, recent developments and future perspectives. [PDF]

Mater Today Bio
Gao Z, Du S, Song J, Gao Y, Peng X, Lin X, E S, Zhao Y, Zhang S.   +8 more
europepmc   +1 more source

Conjugational Complementation Analysis of Transfer-Deficient Mutants of F lac in Escherichia coli

, 1972
Achtman, Mark, Willetts, Neil, Clark, Alvin J.   +2 more
openalex   +2 more sources

Photoacoustic Imaging: Tuning Optical Properties of BODIPY Dyes by Pyrrole Conjugation for Photoacoustic Imaging (Advanced Optical Materials 11/2020) [PDF]

, 2020
Jean Michél Merkes, Twan Lammers, Rajesh Kancherla, Magnus Rueping, Fabian Kießling, Srinivas Banala   +5 more
openalex   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Tuning Photophysical Properties And Esipt Mechanism of 10-Hydroxybenzo[ H ]Quinoline by Introducing Different Conjugation Groups

He Sun, Yan Leng, Hongbo Liu, Chungang Min, Ai‐Min Ren   +4 more
openalex   +1 more source