Results 171 to 180 of about 337,623 (298)

Targeted Intracellular Delivery of Antisense Oligonucleotides via Conjugation with Small-Molecule Ligands

, 2010
Osamu Nakagawa, Xin Ming, Leaf Huang, Rudolph L. Juliano   +3 more
openalex   +2 more sources

Iterative Spectral Mollification and Conjugation for Successive Edge Detection [PDF]

, 2020
Robert E. Tuzun, Jae-Hun Jung
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Enhancing conjugation from E. coli to Streptomyces coelicolor by incorporating traJ into mobilizable plasmids. [PDF]

Appl Microbiol Biotechnol
Valdés-Chiara P, Concha Y, Alonso-Fernández S, Manteca A, Fernández-García G.   +4 more
europepmc   +1 more source

Cu(i)-assisted click chemistry strategy for conjugation of non-protected cross-bridged macrocyclic chelators to tumour-targeting peptides

, 2015
Zhengxin Cai, Barbara T. Y. Li, Edward H. Wong, Gary R. Weisman, Carolyn J. Anderson   +4 more
openalex   +2 more sources

Conjugation of nanomaterials containing rare-earth ion Tb3+ with CD133 monoclonal antibody and its potentials for labeling colon cancer cells (HT-29) [PDF]

, 2020
Le Nhat Minh, Vo Trong Nhan, Nguyễn Thị Nga, Trần Thu Hương, Phung Thi Kim Hue, Đỗ Thị Thảo   +5 more
openalex   +1 more source

A π-Conjugation Extended Viologen as a Two-Electron Storage Anolyte for Total Organic Aqueous Redox Flow Batteries.

Angewandte Chemie, 2018
Jian Luo, Bo Hu, Camden Debruler, T. Liu
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Double-hit approach for novel glycoconjugates combining cytoplasmic glycoengineering and selective chemistry. [PDF]

RSC Chem Biol
Palmieri E, Monaci V, Durante S, Cescutti P, Micoli F, Gasperini G.   +5 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source