Results 181 to 190 of about 570,681 (325)

Conjugation related costs have reduced impact onin silicoplasmid persistence [PDF]

Arthur Newbury
openalex   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Structural Characterization of Linker Shielding in ADC Site-Specific Conjugates. [PDF]

Pharmaceutics
Jaime-Garza M, Waight A, Hudlikar M, Eddins MJ, Rasti ES, Zaragoza JPT, Fayadat-Dilman L, Chrencik JE, Gabelli SB, Chen YT, Noland CL.   +10 more
europepmc   +1 more source

Is There a Third Peripheral Catecholaminergic System? Endogenous Dopamine as an Autocrine/ Paracrine Substance Derived from Plasma DOPA and Inactivated by Conjugation

, 1995
David S. Goldstein, Éva Mezey, Toshimasa Yamamoto, Anders Åneman, Peter Friberg, Graeme Eisenhofer   +5 more
openalex   +2 more sources

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Reprogramming AAV tropism with tumor-associated targeting ligands. [PDF]

Mol Ther Oncol
Trisno SL, Kay MA.
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Conjugation-Mediated Transfer of Antibiotic-Resistance Plasmids Between Enterobacteriaceae in the Digestive Tract ofBlaberus craniifer(Blattodea: Blaberidae)

, 2016
Immacolata Anacarso, Ramona Iseppi, Carla Sabia, Patrizia Messi, Carla Condò, Moreno Bondi, Simona De Niederhäusern   +6 more
openalex   +2 more sources

Improvement of Foaming and Emulsifying Properties of Gluten by Conjugation with Fructose through Maillard Reaction [PDF]

, 2018
Yongling Song, Ruiqi Qin, Shaoming Yang, Li Jianghe, Ruolan Wang   +4 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source