Results 181 to 190 of about 337,623 (298)

Comparative Evaluation of Antibody-Oligonucleotide Conjugation Strategies for Multiplexed Imaging Applications. [PDF]

Lab Invest
Caraccio C, van de Klashorst J, Cherkas S, Ancel S, Kempchen TN, Vazquez G, Goltsev Y, Wang YX, Nolan GP, Hickey JW.   +9 more
europepmc   +1 more source

Phthalimide conjugation as a strategy for in vivo target protein degradation

Science, 2015
Georg E. Winter, Dennis L. Buckley, Joshiawa Paulk, Justin M. Roberts, Amanda L. Souza, S. Dhe-Paganon, J. Bradner   +6 more
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Conjugation strategy shapes antitumor efficacy and enables dose-sparing in non-antibody protein nanoconjugates. [PDF]

Mater Today Bio
Rueda A, Garcia-Leon A, Arena LA, Mendoza JI, Aviñó A, Fabrega C, Eritja R, Paez D, Alba-Castellon L, Vazquez E, Villaverde A, Mangues R, Casanova I, Unzueta U.   +13 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Transfer of <i>bla</i>TEM gene between <i>Salmonella</i> and <i>Escherichia coli</i> under processing conditions of animal products: influence of a copper(II) complex. [PDF]

Front Microbiol
Ribeiro RAC, Guidotti-Takeuchi M, Dumont CF, Buiatte ABG, de Araújo Brum B, Martins TJ, Ramos LMS, Guerra W, Polveiro RC, de Melo RT, Rossi DA.   +10 more
europepmc   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Structural Characterization of Linker Shielding in ADC Site-Specific Conjugates. [PDF]

Pharmaceutics
Jaime-Garza M, Waight A, Hudlikar M, Eddins MJ, Rasti ES, Zaragoza JPT, Fayadat-Dilman L, Chrencik JE, Gabelli SB, Chen YT, Noland CL.   +10 more
europepmc   +1 more source

Conjugation related costs have reduced impact on in silico plasmid persistence [PDF]

Arthur Newbury
openalex   +1 more source

Rescuing of neuroprotective peptides by chemical conjugation with lipophilic active pharmaceutical ingredients

, 2020
Sara C. Silva-Reis, Ivo E. Sampaio‐Dias, Xerardo García‐Mera, José E. Rodríguez‐Borges   +3 more
openalex   +2 more sources