Results 211 to 220 of about 570,681 (325)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Universal Microfluidic Platform for Multifunctional Surface Modification of Small Extracellular Vesicles. [PDF]

J Extracell Vesicles
Hong Y, Zhang H, Zeng L, Wang Y, You Y, Shen J, Hao R, Lu L, Hu S, Yu Z, Li C, Yang H.   +11 more
europepmc   +1 more source

Conjugational Complementation Analysis of Transfer-Deficient Mutants of F lac in Escherichia coli

, 1972
Achtman, Mark, Willetts, Neil, Clark, Alvin J.   +2 more
openalex   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Methods for Conjugating Antibodies with Quantum Dots. [PDF]

Molecules
Sokolov P, Knysh A, Kriukova I, Samokhvalov P, Kistenev YV.   +4 more
europepmc   +1 more source

Strong and oriented conjugation of nanobodies onto magnetosomes for the development of a rapid immunomagnetic assay for the environmental detection of tetrabromobisphenol-A

, 2018
Jinxin He, Jiesheng Tian, Junjie Xu, Kai Wang, Ji Li, Shirley J. Gee, Bruce D. Hammock, Qing X. Li, Ting Xu   +8 more
openalex   +2 more sources

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Unveiling the electron-phonon coupling anisotropy in 2D covalent organic frameworks. [PDF]

Chem Sci
Zhang Y, Dai Z, Tan Z, Yang H, Xu C, Zhou S, Li ZM.   +6 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Beyond degradation tags: How FAT10 and ubiquitin shape substrate energy landscapes. [PDF]

Essays Biochem
Ravichandran A, Sivakumar A, Das R.
europepmc   +1 more source