Results 41 to 50 of about 567,992 (281)

A Hardware Platform Framework for an Intelligent Vehicle Based on a Driving Brain

open access: yesEngineering, 2018
The type, model, quantity, and location of sensors installed on the intelligent vehicle test platform are different, resulting in different sensor information processing modules.
Deyi Li, Hongbo Gao
doaj   +1 more source

Cooperative Merging Strategy Between Connected Autonomous Vehicles in Mixed Traffic

open access: yesIEEE Open Journal of Intelligent Transportation Systems, 2022
In this work we propose a new cooperation strategy between connected autonomous vehicles in on-ramps merging scenarios and we implement the cut-in risk indicator (CRI) to investigate the safety effect of the proposed strategy.
Eleonora Andreotti   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Research and prospect of intelligent connected vehicle test scheme

open access: yesDianxin kexue, 2023
The comprehensive test and evaluation of intelligent connected vehicles is an important guarantee for the safety of intelligent connected vehicles on the road and the smooth landing of the industry.Based on the test status, test technology path, test ...
Dongsheng WU   +3 more
doaj   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Automotive Software in Connected and Autonomous Electric Vehicles: A Review

open access: yesIEEE Access, 2019
In the last decade, electric vehicles (EVs) have emerged as a sustainable transportation alternative to traditional internal combustion engine (ICE) cars, with automotive software as the key driver behind the advancements.
Hrvoje Vdovic   +2 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Symbolic Imitation Learning: From Black-Box to Explainable Driving Policies

open access: yesApplied Sciences
Current imitation learning approaches, predominantly based on deep neural networks (DNNs), offer efficient mechanisms for learning driving policies from real-world datasets.
Iman Sharifi   +2 more
doaj   +1 more source

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