Results 91 to 100 of about 244,589 (288)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A feasibility study of a short lung ultrasound protocol as a screening method for fibrotic interstitial lung disease [PDF]

ARP Rheumatology
Aims: Interstitial lung disease (ILD) represents a common complication of connective tissue diseases (CTD). Early detection of ILD is critical since patients often remain asymptomatic during the initial stages.
Sara Braga, André Carvalho, Márcio Rodrigues, Pedro Madureira, Raquel Miriam Ferreira, André Terras Alexandre, Natália Melo, Patrícia Caetano Mota, António Morais, Hélder Novais Bastos   +9 more
doaj  

Precipitating Auto-Antibodies in the Connective Tissue Diseases [PDF]

, 1962
John R. Anderson, K.G. Gray, J. Swanson Beck, W. Watson Buchanan, A. James McElhinney   +4 more
openalex   +1 more source

Recognition of Connective Tissue Disease-Related Interstitial Pneumonia Based on Histological Score—A Validation Study of an Online Diagnostic Decision Support Tool [PDF]

, 2021
Mutsumi Ozasa, Yoshiaki Zaizen, Kazuhiro Tabata, Kensuke Kataoka, Shuntaro Sato, Andrey Bychkov, Noriho Sakamoto, Hiroshi Mukae, Yasuhiro Kondoh, Junya Fukuoka   +9 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Pauci-Immune Crescentic Glomerulonephritis in Connective Tissue Disease

Case Reports in Rheumatology, 2016
Pauci-immune crescentic glomerulonephritis is commonly seen in ANCA-associated vasculitis but it is rarely seen during the course of other connective tissue diseases like lupus or Sjogren’s syndrome or MCTD.
Supraja Yeturi, Mary Cronin, Adam Robin, Campbell Lorna, Ann K. Rosenthal   +4 more
doaj   +1 more source

LONG-TERM TREATMENT WITH SITAXSENTAN IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH CONNECTIVE TISSUE DISEASE (PAH-CTD) [PDF]

, 2005
Reda E. Girgis, Adaani Frost, Nick Hill, David Langleben, Vallerie V. McLaughlin, R.J. Oudiz, Terrance Coyne   +6 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Utility of the AVISE Connective Tissue Disease test in predicting lupus diagnosis and progression [PDF]

, 2020
Emily C. Liang, Mihaela Taylor, Maureen McMahon   +2 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source