Results 191 to 200 of about 542,433 (374)
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
Properties of Connective Tissue and Periodontal Disease
, 1976 Masaharu SHIMIZU
openalex +2 more sources
FEBS Open Bio, Volume 15, Issue 4, Page 661-673, April 2025.Compared to normal tissues, NPC1 expression is significantly elevated in hepatocellular carcinoma tissues. Our findings indicate that NPC1 plays a key role in regulating neutrophil recruitment within the tumor, which is a critical factor in the progression of hepatocellular carcinoma and is closely linked to poor patient outcomes.
Songhai Yang +3 more
wiley +1 more source
FEBS Open Bio, Volume 15, Issue 4, Page 622-633, April 2025.We explored the role of FSH on the synovium and found that FSH was able to mediate the development of osteoarthritis by acting on the FSH receptor (FSHR) to promote the production and release of inflammatory factors through the activation of the NFκB signaling pathway. Previous studies have suggested that women with higher follicle‐stimulating hormone (
Yu Chen +6 more
wiley +1 more source
Lysosomes and the connective tissue diseases [PDF]
Journal of Clinical Pathology, 1978 openaire +4 more sources
Studies on Gingival Connective Tissue Components of Patients with Periodontal Disease
, 1977 Takao Miki +7 more
openalex +2 more sources
Acta Biomedica Scientifica, 2012 The article presents individual features of metabolism of connective tissue in patients with, different terms of formation of vibration disease. The assessment of metabolic disorders in connective tissue of patients with vibration disease for prediction ...
E. L. Smirnova +2 more
doaj
CDK5 interacts with MST2 and modulates the Hippo signalling pathway
FEBS Open Bio, Volume 15, Issue 4, Page 647-660, April 2025.By using a yeast‐two‐hybrid system, immune precipitation and a proteomics approach, we identify a novel interaction between CDK5 and MST2, which modulates the mechano‐sensitive Hippo signalling pathway in a liver tumour cell line. MST2 (STK3) is a major upstream kinase in the Hippo signalling pathway, an evolutionary conserved pathway in regulation of ...
Mehak Passi +5 more
wiley +1 more source
FEBS Open Bio, Volume 15, Issue 5, Page 836-855, May 2025.Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy +14 more
wiley +1 more source