Objectives Evaluate the efficacy and safety of baricitinib in paediatric patients with active JIA‐U or chronic anterior ANA‐positive uveitis, who had an inadequate response to MTX or bDMARDs. Methods JUVE‐BRIGHT was an open‐label, active‐controlled, Phase‐3 multicentre trial which utilized a novel design, including 1:1 randomization to an active ...
Athimalaipet V. Ramanan +7 more
wiley +1 more source
Effect of sirolimus on connective tissue disease related refractory thrombocytopenia: clinical efficacy and immunomodulatory mechanism. [PDF]
Li X +7 more
europepmc +1 more source
Objective There are no US Food and Drug Administration–approved therapies for Raynaud phenomenon (RP) in the United States. Clinical trials have been challenged by study design. Important advances in RP patient‐reported outcome measures and mechanistic quantification allow RP‐related pain characterization.
Tracy M. Frech +4 more
wiley +1 more source
Dilemmas in the Management of Digital Ulcers in Systemic Sclerosis-Mixed Connective Tissue Disease: Lessons From a Case Report. [PDF]
Dadhich K, Shah M, Jain A, Gill N.
europepmc +1 more source
14. A severe case of connective tissue disease related interstitial lung disease in a young woman [PDF]
Kate Grant +6 more
openalex +1 more source
Diffusion‐Weighted Imaging for the Evaluation of the Sacroiliac Joint in Pediatric Patients
Background Maturational signal in the sacroiliac joint (SIJ) of skeletally immature youth is often misinterpreted as inflammation. Diagnostic tools that improve specificity are greatly needed. Apparent diffusion coefficient (ADC) values from diffusion‐weighted imaging (DWI), when used with standard imaging, may enhance diagnostic accuracy.
Michael L. Francavilla +6 more
wiley +1 more source
Objective This systematic review aimed to assess the diagnostic accuracy of algorithms used to identify rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) in electronic health records (EHRs). Methods We searched MEDLINE, Embase, and CENTRAL databases and included studies that validated case definitions against a reference standard such ...
Constanza Saka‐Herrán +10 more
wiley +1 more source
Stable Undifferentiated Connective Tissue Disease and CNS Demyelination: A Case Report and a Literature Review. [PDF]
Pachner AR.
europepmc +1 more source
Beyond Inflammation: Why Understanding the Brain Matters in Inflammatory Arthritis
Persistent pain remains a major challenge in inflammatory arthritis, even when joint inflammation is well controlled. Pain and associated symptoms such as fatigue cannot be explained by peripheral inflammation alone but reflect altered central pain processing. These changes may arise through “top‐down” mechanisms, reflecting pre‐existing dysfunction in
Eoin M. Kelleher +2 more
wiley +1 more source
Diagnosis of Systemic Rheumatic Disease Using the Connective Tissue Disease Screen. [PDF]
Kapuczinski A +4 more
europepmc +1 more source

