Results 61 to 70 of about 401,424 (306)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Generalized connective tissue disease in Crtap-/- mouse. [PDF]

PLoS ONE, 2010
Mutations in CRTAP (coding for cartilage-associated protein), LEPRE1 (coding for prolyl 3-hydroxylase 1 [P3H1]) or PPIB (coding for Cyclophilin B [CYPB]) cause recessive forms of osteogenesis imperfecta and loss or decrease of type I collagen prolyl 3 ...
Dustin Baldridge, Jennifer Lennington, MaryAnn Weis, Erica P Homan, Ming-Ming Jiang, Elda Munivez, Douglas R Keene, William R Hogue, Shawna Pyott, Peter H Byers, Deborah Krakow, Daniel H Cohn, David R Eyre, Brendan Lee, Roy Morello   +14 more
doaj   +1 more source

Capillaroscopy in 2016 : new perspectives in systemic sclerosis [PDF]

, 2016
Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by early impairment of the microvascular system. Nailfold microangiopathy and decreased peripheral blood perfusion are typical clinical aspects of SSc.
Cutolo, M, Llado, A, Paolino, S, Pizzorni, C, Ruaro, B, Smith, Vanessa, Sulli, A   +6 more
core   +1 more source

The pathogenesis of tendinopathy. A molecular perspective [PDF]

, 2004
There are many publications that discuss the aetiology, diagnosis and treatment of the various forms of tendinopathy, but few are based on conclusive scientific evidence.
Riley, GP
core   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Connective tissue disease-associated interstitial lung disease

Jornal Brasileiro de Pneumologia
Connective tissue disease-associated interstitial lung disease (CTD-ILD) represents a group of systemic autoimmune disorders characterized by immune-mediated organ dysfunction.
Karin Mueller Storrer, Carolina de Souza Müller, Maxwell Cássio de Albuquerque Pessoa, Carlos Alberto de Castro Pereira   +3 more
doaj   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Role of toll-like receptor 4 in skeletal muscle damage in chronic limb-threatening ischemia

JVS - Vascular Science
Objective: Toll-like receptors (TLRs) are key pattern recognition receptors in the innate immune system. In particular, the TLR4-mediated immune response has been implicated in ischemia-induced tissue injury. Mounting evidence supports a detrimental role
Ali Navi, PhD, FRCS, Hemanshu Patel, MRCS, Xu Shiwen, PhD, Daryll Baker, PhD, FRCS, David Abraham, PhD, Janice Tsui, MD, FRCS   +5 more
doaj   +1 more source

Bronchiolitis obliterans. [PDF]

, 1989
Bronchiolitis obliterans in the adult patient is a relatively uncommon and vexing clinical entity. This confusion results because this pathologic finding occurs in a variety of diverse clinical settings.
King, TE
core