Results 121 to 130 of about 3,946,313 (310)

[Interstitial Lung Disease associated with Connective Tissue Diseases].

Interstitial Lung Disease associated with Connective Tissue Diseases Abstract: Interstitial lung diseases (ILD) are in up to one-third of cases associated with connective tissue diseases (CTD).
Guler, Sabina A, Sarbu, Adela
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Interstitial lung disease and connective tissue diseases

, 2016
Lung involvement in rheumatologic diseases has a broad spectrum of clinical and radiological presentations, from acute inflammatory to chronic, fibrosing predominance.
Geiser, Thomas, Guler, Sabina
core   +1 more source

A multicenter study of long-term outcomes of relapsing polychondritis in Iran

Scientific Reports
Relapsing polychondritis (RP) is a systemic immune mediated disease characterized by recurrent episodes of inflammation in various cartilage-rich areas. RP may cause extensive tissue destruction and is associated with significant morbidity and mortality.
Mehdi Jafarpour, Maryam Saberivand, Maryam Saemi, Maryam Sahebari, Seyedmostafa Seyedmardani, Mansour Salesi, Sarah Hosseinpoor, Tahereh Faezi, Kamal Esalatmanesh, Mehrzad Hajialilo, Sousan Kolahi, Zahra Myrfeizi, Alireza Khabbazi   +12 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The influence of type I diabetes mellitus in periodontal disease induced changes of the gingival epithelium and connective tissue

, 2015
Periodontal disease constitutes the most frequent chronic diseases in human dentition. Bacterial plaque is the main etiologic agent, although it is the host immune response that causes periodontal tissue destruction.
Lorencini, M, Reis, JRR, Stach-Machado, DR, Carvalho, HF, Cagnon, VHA, Silva, JAF   +5 more
core   +1 more source

Strategy for connective tissue diseases from viewpoint of vascular endothelial damage [PDF]

, 2007
Although prognosis of connective tissue diseases has been much improved by use of corticosteroids and immunosuppressants, resistant cases still exist with dysfunction of various organs. Especially, interstitial pneumonitis (IP) and pulmonary fibrosis are
Nozaki, Yuji, Ikoma, Shinya, Tamaki, Chise, Kishimoto, Kazuya, Yamagata, Toshiaki, Sugiyama, Masafumi, Funauchi, Masanori, Shimazu, Hideki, Kinoshita, Koji   +8 more
core   +1 more source

Serum Amyloid A as a Marker of Persistent Inflammation and an Indicator of Cardiovascular and Renal Involvement in Patients with Rheumatoid Arthritis

Mediators of Inflammation, 2014
Objectives. Rheumatoid arthritis (RA) is a systemic, inflammatory disease. Serum amyloid A (SAA) is an acute-phase protein, involved in pathogenesis of atherosclerosis.
Bożena Targońska-Stępniak, Maria Majdan   +1 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Walsh & Hoyt: Connective Tissue Diseases

, 2005
If weakness of the wall of the artery underlies development of an aneurysm, aneurysms should develop with higher frequency in patients with diseases that affect collagen. Indeed, some connective tissue diseases, particularly fibromuscular dysplasia (FMD),
Steven A. Newman, MD
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