Results 141 to 150 of about 1,337,423 (351)

Glutathione has cell protective and anti-catabolic effects in articular cartilage without impairing the chondroanabolic phenotype

Heliyon
Joint injuries and consequent oxidative stress is a high-risk factor for developing post-traumatic osteoarthritis (OA). While antioxidative therapy using N-acetylcysteine (NAC) has cell- and chondroprotective effects following cartilage injury, it ...
Svenja Maurer, Michael Fuchs, Rolf E. Brenner, Jana Riegger   +3 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Taurine supplementation and systemic lupus erythematosus in preclinical studies: a systematic review of clinical outcomes and underlying mechanisms

Amino Acids
Taurine (Tau) is a sulfur-containing amino acid that has therapeutic roles in several diseases, including inflammatory conditions. The involvement of Tau in modulating systemic lupus erythematosus (SLE) autoimmunity has been indicated in preclinical ...
Aida Malek Mahdavi, Zeinab Javadivala, Niloufar Orooji   +2 more
doaj   +1 more source

Recent developments in connective tissue disease associated pulmonary arterial hypertension

International Journal of Cardiology Congenital Heart Disease
Connective tissue disease associated pulmonary arterial hypertension (CTD-PAH) has benefited from the major treatment advances that have occurred within pulmonary hypertension over the past three decades.
Stefano Rodolfi, Voon H. Ong, Christopher P. Denton   +2 more
doaj   +1 more source

BMQ [PDF]

, 1964
BMQ: Boston Medical Quarterly was published from 1950-1966 by the Boston University School of Medicine and the Massachusetts Memorial ...
Barnard, Donna R., Byrne, John J., Carey, Robert J., Chen, Joyce L., Chen, S. C. Andrew, Cohen, Marcia E., Constantine, Herbert, Dearing W. P., Ebaugh, Franklin G., Jr., England, Mary Jan, England, Robert A., Golub, Burton P., Goodman, Max L., Ingelfinger, Franz J., Kaufman, S. A., Keefer, Chester S., Levitan, Ruven, McLellan, Patricia A., Melby, James C., Mitchell, Anita, Moyer, Elizabeth K., Nidorf, Louis, Osler, Leonard D., Scheff, Saul, Seifert, Donald E., Sherry, S. Norman, Taylor, Charles E., Tedeschi, C. G., Walker, Sydnay, III, Weiner, Leonard, Wold, Sylvester M.   +30 more
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Intradermal infections by chigger mites (Hannemania spp.) in the Andean frog Telmatobius atacamensis (Anura, Telmatobiidae) [PDF]

, 2015
Here, we report the infection of adults of the Andean frog Telmatobius atacamensis (Anura, Telmatobiidae) by leeuwenhoekiid mites of the genus Hannemania and describe the histological characteristics of the normal and infected skin and the mite's larval ...
Goldberg, Francisco Javier, Quinzio, Silvia Inés   +1 more
core  

Connective tissue disease registries [PDF]

Arthritis & Rheumatism, 1997
M D, Mayes, E H, Giannini, L M, Pachman, J P, Buyon, P, Fleckman   +4 more
openaire   +2 more sources