The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
E04 Initial Results from a Combined Rheumatology/Dermatology Connective Tissue Disease Clinic in Belfast [PDF]
, 2016 Louise McDonald
openalex +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao +10 more
wiley +1 more source
Revisiting the mortality of France and Italy with the multiple-cause-of-death approach [PDF]
In this paper, we use the multiple cause-of-death approach to compare the mortality profiles of France and Italy in 2003. Our analysis leads to a substantial re-evaluation of the role played by certain conditions in the process leading to death ...
Aline Desesquelles +6 more
core
FRI0227 A USABILITY SURVEY OF WRIST MOUNTED DISPOSABLE HEAT PAD ON RAYNAUD'S PHENOMENON IN PATIENTS WITH CONNECTIVE TISSUE DISEASES [PDF]
, 2020 Naoto Azuma +3 more
openalex +1 more source
Current therapeutic strategies in connective tissue disease-related interstitial lung disease: introduction to the special issue [PDF]
, 2021 Gian Luca Erre, Arduino A. Mangoni
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Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon +12 more
wiley +1 more source
Prolonged Sensory and Motor Deficit Following Short-Term Lumbar Epidural Analgesia in a Patient with Mixed Connective Tissue Disease [PDF]
, 2002 Greta M. Palmer +3 more
openalex +1 more source
Microvascular damage – a marker of specific organ involvement in mixed connective tissue disease? [PDF]
, 2021 Sylwia Ornowska +4 more
openalex +1 more source