Results 91 to 100 of about 1,643,357 (310)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

On so-called adversative nisi

Pallas, 2016
This paper is concerned with certain semantic and pragmatic properties of the Latin connector nisi. The discussion is structured in three sections. The first gives a short introduction of the main functions of nisi identified in the scholarship on the ...
Giovanbattista Galdi
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

RADAR-base/radar-helm-charts: radar-s3-connector-0.3.2 [PDF]

<p>A Helm chart for RADAR-base s3 connector. This connector uses Confluent s3 connector with a custom data transformers. These configurations enable a sink connector.
Joris Borgdorff, Pauline Conde, Heet Sankesara, Yatharth Ranjan, Keyvan, Bastiaan   +5 more
core   +1 more source

Osseointegration implant connector (A: OTN connector, B: OPL/Hermle connector). [PDF]

, 2020
Osseointegration implant connector (A: OTN connector, B: OPL/Hermle connector).
J. P. Frölke (8550789), R. A. Leijendekkers (8550792), R. Atallah (8550780), L. Verhamme (8550786), H. van de Meent (8550783)   +4 more
core   +1 more source

Analytical and Experimental Investigation of a Three-Module VLFS Connector Based on an Elastic Beam Model

Journal of Marine Science and Engineering
Very large floating structures (VLFSs) typically employ a modular design approach to mitigate significant hydroelastic loads. A mooring system is commonly employed to maintain the position and heading of a VLFS against the forces of waves, wind, and ...
Yongheng Wang, Xuefeng Wang, Shengwen Xu, Lei Wang   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source