Results 121 to 130 of about 55,399 (296)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
, 2018 A critical issue for architectural design is the nature of the glue, or connectors, with which a system's parts are combined. Thus an important first step toward improving our ability to compose parts is to make to make connectors explicit semantic ...
David Garlan (5359970)
core +1 more source
BuildingsCurrent research on the stress mechanisms of composite connectors within steel–concrete structures of bridge towers is sparse, and there is a lack of established experimental methods and finite element modeling techniques for studying these mechanisms ...
Yunwei Du +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Rethinking software connectors
, 2007 Existing work on software connectors shows significant disagreement on both their definition and their relationships with components, coordinators and adaptors.
Kell, Stephen, Stephen Kell
core +1 more source
Research on the Elastic Stiffness of Stud–PBL Composite Shear Connectors in Composite Bridge Pylons
BuildingsThe application of steel–concrete composite structures in the pylons of long-span cable-stayed bridges can effectively address the issue of insufficient structural stiffness.
Qinhe Li +4 more
doaj +1 more source